Sequential Changes of Serum Transaminase and Abdominal Sonography in Patients with Suspected Dengue Fever

於1988年秋天登革熱在南台灣流行。本研究收集當時因發燒至高雄醫學院附設醫院急診室就診兩次以上疑似登革熱之成年病人共113名之286次AST及ALT資料，加以分析。結果發現AST自發病後逐日上升，在發病後第六天，全部高於正常值，且約為第一天之9.25倍。其系列變化為：發病後第三天AST開始明顯上升。第七或八天到達最高點後開始下降，約三週恢復正常。ALT也有相同的變化唯上升幅度較小且時間較慢。部份病人的超音波發現有膽囊璧肥厚、脾腫大及腹水，這些變化在病＇降陝復後消失。本研究嘗試描述登革熱病人AST、ALT及腹部超音波之系列變化以供對登革熱、急性肝炎及急性膽囊炎鑑另lJ診斷之參考。

關鍵字

無資料

並列摘要

Southern Taiwan experienced a dengue (type 1) outbreak in the autumn of 1988. One hundred and thirteen febrile patients suspected as having dengue infection were seen in the emergency room of the Kaohsiung Medical College Hospital. These patients were recruited for this study. Two hundred and eighty-six sequential serum aspartate transaminase (AST) and alanine transaminase (ALT) data from these patients were analyzed. Data analysis showed serum AST had inDreased daily and all data were out of normal range from day 6 of the illness. Compared to the AST level on the first day of the illness, the AST level was noted to elevate to an average of 9.25 folds on day 6. The sequential changes of AST were as follows: AST had elevated since the third ill-day in most cases and reached a peak on the 7th or 8th ill-day. It then declined gradually from the 8th ill-day and became normal about 3 weeks later. The changes of ALT level were about the same as AST but had later onset and lower peak. Abdominal sonographic examinations showed thickening of the gall bladder wall, splenomegaly and ascites in some patients during acute stage of the illness and recovered completely after patients recovered from the dengue attack. The sequential change of serum transaminase levels and sonographic findings were compatible. These findings may be used as a reference for the differential diagnosis among dengue fever, acute hepatitis and acute cholecystitis.

並列關鍵字

dengue ； transaminase ； songraphy.

國際替代計量

Sequential Changes of Serum Transaminase and Abdominal Sonography in Patients with Suspected Dengue Fever

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