Taiwan's First Case of Perinatal Transmission of HIV Confirmed by a Modified Western Blot Test

一位25歲中國婦女，於民國77年12月14日發現其為HIV抗體陽性後，隨即篩檢其六個月大的女嬰及其美國籍丈夫，並發現此位女嬰亦呈抗體陽性反應，而她的先生在這五個月的追蹤裡，其HIV抗體試驗一直為陰性反應。本次的追蹤共可分為三個階段，分別於民國77年12月17日、民國78年1月27日及民國78年4月14日完成。若以標準式的西方墨點法來檢驗這三個時期的血清時，在第一階段出現於此女嬰色條上的色帶有：p15,p24,p31,p55和gp12o/gp160，若以修改式的西方墨點法來檢驗，則出現之色帶為p15,p24,p31,p53,p55,p64和gp120/gp1600此後，該女嬰在第二、三檢驗階段出現的色帶除了第一階段已有的色帶外，又出現p53和gp41，而且各色帶濃度逐漸增加。當使用修改式的西方墨點法時，此女嬰在不同階段所抽的血清裡，出現於色條上的色帶強度皆比標準式的為濃，可見該女嬰之HIV抗體為自體產生外且有逐漸增加的趨勢。此位母親可能是受婚前歐洲籍男朋友所感染，而這位女嬰則經由剖腹生產且是餵牛乳長大的，出生後亦無明顯的感染途徑發生，顯然此位女嬰可能已在子宮內受到HIV的感染。

關鍵字

無資料

並列摘要

A 25-year-old Chinese woman, was found HIV antibody positive on December 14, 1988. During our follow-up, we tested her American husband and found him to be seronegative. Unfortunately, her six-month-old infant was seropositive. The standard Western blot test was used in the first stage of analysis. The bands which appeared on the infant’s strip were p15, p24, p31, p55 and pgl20/gpl60, but using the modified Western blot test the bands which appeared were p15, p.24, p31, gp4l, P53 p55, p64 and gpl20/gpl60. All the bands appearing on the infant’s strips which used a modified Western blot test had higher intensities than those of a standard procedure. The mother was apparently infected with HIV through intercourse with her ex-boyfriend, who was a European. AZT was given to the mother because her T4 cell count was 338 per i1 and because of persistent cervical lymphadenopathy. The infant, which was bottle-fed and had been delivered by caesarian section, may have become HIV infected during the uterine stage.

並列關鍵字

Perinatal transmission ； HIV ； Westrn blot test

國際替代計量

Taiwan's First Case of Perinatal Transmission of HIV Confirmed by a Modified Western Blot Test

全文下載

主題瀏覽