- 期刊
Lactoferrin in Rheumatoid Arthritis and Systemic Lupus Erythromatosus
Lactoferrin在類風濕性關節炎和系性紅斑狼瘡之表現
摘要
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are prototypes of autoimmune diseases. In order to assess the inflammatory status in these conditions, lactoferrin, stored in specific granules of neutrophils, was measured in serum samples of patients with SLE and RA. In RA, the mean serum lactoferrin level ( 1221.397 ± 289.476 ng/ml ) was significantly higher than that in normal individuals ( 753.364 ± 124.063 ng/ml). Surprisingly, there were no significant differences between active SLE ( 672.682 ± 356.154 mg/mi ) and inactive SLE ( 642.267 ± 270.456 ng/ml ). Still, no differences were found between normal volunteers, active SLE and inactive SLE. Serum lactoferrin in SLE correlated significantly with CRP (Rs =0.4089, p＜0.01),but not with complement level and ANA titers. Thus in RA serum lactoferrin was highly elevated and this indicated that PMN in systemic circulation was activated. In SUE the correlation of CRP with lactoferrin reflected the role of later protein in inflammation.
關鍵字
無資料並列摘要
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are prototypes of autoimmune diseases. In order to assess the inflammatory status in these conditions, lactoferrin, stored in specific granules of neutrophils, was measured in serum samples of patients with SLE and RA. In RA, the mean serum lactoferrin level ( 1221.397 ± 289.476 ng/ml ) was significantly higher than that in normal individuals ( 753.364 ± 124.063 ng/ml). Surprisingly, there were no significant differences between active SLE ( 672.682 ± 356.154 mg/mi ) and inactive SLE ( 642.267 ± 270.456 ng/ml ). Still, no differences were found between normal volunteers, active SLE and inactive SLE. Serum lactoferrin in SLE correlated significantly with CRP (Rs =0.4089, p＜0.01),but not with complement level and ANA titers. Thus in RA serum lactoferrin was highly elevated and this indicated that PMN in systemic circulation was activated. In SUE the correlation of CRP with lactoferrin reflected the role of later protein in inflammation.
被引用紀錄
延伸閱讀
- Huang, C. M., Chen, C. L., Lin, T. H., & Wang, H. J. (1999). 類風濕性關節炎和退化性關節炎病患之血清和關節液腫瘤壞死因子及接受體之偵測. Mid-Taiwan Journal of Medicine, 4(2), 109-115. https://doi.org/10.6558/MTJM.1999.4(2).6
- Chang, W. Y., & Chen, G. S. (2005). 間質肉芽腫性皮膚炎合併類風濕性關節炎－病例報告. 中華皮膚科醫學雜誌, 23(2), 91-95. https://doi.org/10.29784/DS.200506.0005
- 劉瀚文（2005）。抗伯氏舒螺旋菌表面蛋白A抗體與類風濕關節炎之研究〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2005.00076
- Lin, S. J., Van, D. C., & Huang, J. L. (2000). 全身性年青型風濕性關節炎轉化為紅斑性狼瘡－一病例報告. Formosan Journal of Rheumatology, 15(1&2), 15-20. https://doi.org/10.6313/FJR.200004_15(1_2).0003
- 林文香、夏萍絗、楊文山、洪志美（1999）。全身性紅斑狼瘡及類風濕性關節炎女病患的身體、心理、社會功能探討。護理研究，7(3)，261-275。https://doi.org/10.7081/NR.199906.0261