Intramuscular Injection Associated Gluteal Fibrotic Contracture and Hepatitis B Virus Infection among Schoolchildren

大臀肌肌肉纖維化拘縮症（青蛙肢症）與B型肝炎病毒感染兩者由肌肉注射引起

葛應欽(Ying-Chin Ko) ； 鍾蝶起(Dye-Chii Chung) ； 白秀華(Hsiu-Hua Pai)

《The Kaohsiung Journal of Medical Sciences》 7卷7期 (1991/07) Pp. 358-362

https://doi.org/10.6452/KJMS.199107.0358

摘要

流行病學研究報告指出肌肉纖維化拘縮症可由肌肉注射引起，B型肝炎病毒感染也可經由打針途徑而來。為了瞭解這兩者是否同時由肌肉注射引起，以病例對照研究62位經醫師診斷大臀肌肌肉纖維化拘縮症的學童，及經配對性別、年齡、居住地區的同班同學62位的有關狀況，結果發現病例組62位都曾經接受醫療肌肉注射，比對照組的57位更高（p=0.029），而且在B型肝炎病毒感染盛行率差異比，病例組為對照組3倍（95%信賴區間1.1-7.8）；在大臀肌肌肉纖維化拘縮症，B型肝炎病毒感及肌肉注射盛行率的地區，三者的關係相當密切。

並列摘要

A case control study was carried out to determine the exposure factors of gluteal fibrotic contracture (GFC). Sixty two school children were taken as the case group and were matched for sex, age and village of residence with 62 of their classmates constituting the control group. It was found that all 62 members of the case group had received intramuscular (IM) injections at some time prior to the onset of GFC, while only 57 of the control group had received IM injections. This difference is a statistically significant (p=0.029). Injection sites on both buttocks were higher in the case group than among the controls. The odds ratio for the prevalence of hepatitis B virus infection (HBV) in the case group as compared to the control group was 3.0 (95% CI 1.1-7.8). A trend correlation was found between the annual frequency of IM injection, GFC and HBV infection. We concluded that IM injections played an important role in GFC and added to the risk of HBV infection, because they had been administered by improperly sterilized reusable syringes in an area where both GFC and HBV infections were prevalent and IM injection was common.

並列關鍵字

gluteal fibrotic contracture ； hepatitis B virus infection ； intramuscular injection