- 期刊
鼻咽癌病人尿液多胺化物的研究評估
Evaluation of Urinary Polyamines In Patients With Nasopharyngeal Carcinoma
摘要
為了研究探討鼻咽癌病人（Nasopharyngeal carcinoma；NPC）的尿液多胺化物（Urinay polyamines；U-Pa）之臨床診斷意義，本研究採用acylpolyamine amidohydrolase和putrescine oxidase等酵素來測定分析NPC患者之U-Pa。同時測定其血清癌胚胎抗原（serum carcinoembryonic antigen；S-CEA）以資比較評估。本實驗以高雄醫學院放射線治療科的NPC病人在放射線治療科的NPC病人為研究對象，研究結果顯示：NPC病人在放射線治療期間其U-Pa值顯著增加但當停止治療後則明顯降低，而且在治療期者之U-Pa較停止治療後坡呈較高值的陽性率。而於S-CEA的測定則無比種情形，故U-Pa值的追蹤檢查可考慮做為治療癌症療效的評估，惟必須再做進一步的研究。至於其在癌症初期診斷上的敏感度只有22%，所以不適用於癌症之篩檢。雖然如此，但因U-Pa之測定具有簡單方便又快速及反應治效果等特性，所以U-Pa值的測定在NPC病人的臨床研究上應該是值得深入探討的檢驗方法。
關鍵字
無資料並列摘要
A new simple enzymatic assay utilizing an acylpolyamine amidohydrolase and putrescine oxidase was adopted for measuring uninary polyamines (U-Pa). Serum carcinoembryonic antigen (S-CEA) was determined for comparison. The study population consisted of patients with pathologically proven nasopharynegeal carcinoma (NPC) who were referred to Kaohsiung Medical College Hospital. We found that polyamine levels were markedly when the treatments was completed. Thus mean polyamines and the positive rate of polyamine elevation was higher in patients suffering form an active stage of the disease than in patients whose cancer had stabilized. However, the level of carcinoembryonic antigen was not elevated whilst undergoing radiotherapy. Therefore, routine measurement of polyamine levels may have a clinical utility in monitoring the disease state of the tumor. However, the low sensitivity of U-Pa test (22%) precludes its use as an effective screening method for this condition. Nevertheless, because of its simplicity, convenience and rapidity for monitoring NPC, U-Pa test should be considered a valuable tool in the clinical investigation of NPC patients.
延伸閱讀
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