Nonfunctioning Pituitary Adenoma

非功能性腦垂腺瘤

洪純隆(Shen-Long Howng) ； 王致仁(Chin-Jen Wang)

《The Kaohsiung Journal of Medical Sciences》 8卷8期 (1992/08) Pp. 412-416

https://doi.org/10.6452/KJMS.199208.0412

摘要

大多數腦垂腺腺瘤都和荷爾蒙的分泌過量有關，但仍有四分之一病人在臨床上或化學檢查呈現非分泌性腺瘤的特性。高雄醫學院腦神經外科在過去五年內共為94個腦垂腺瘤病例施行手術。術後病理切片、免疫組織化學染色法和電子顯微鏡檢查，證實有14例為非功能性腦垂腺瘤，其中6例經α─subunit染色呈現陽性反應。
本文就腦垂腺非功能性腺瘤的臨床及生化學檢查、診斷、治療及預後做一詳盡分析。

並列摘要

A total of 14 patients (8 males and 6 females) with nonfunctional pituitary adenomas were diagnosed and underwent surgi-cal intervention at the Kaohsiung Medical College Hospital between 1986 and 1991. Their ages ranged from 20 to 68 years with an aver-age of 49.7 years. Eight adenomas were composed of small polygonal cells with chromophobic cytoplasm and other six were of large cells with pale eosinophilic granular cytoplasm. Immunohistochemical staining had negative staining of prolactin (PRL), growth hormone (GH), adrenal corticotropic hormone (ACTH) and thyroid stimulating hormone (TSH) in all cases, but scattered or wide spread cells con-taining alpha-subunit of glycoprotein hormones were found in 6 cases.
Hormonal hypersecretion was absent in all of the clinical and biological pictures, as was reactivity to immunohistochemical examina-tion. There were either very few signs of secretory activity, or none at all. CT and MRI scanning revealed 13 macroadenomas (92.9%) and one microadenoma. In seven cases, local invasion or suprasellar extention resulted in decreased visual acuity, but the most common clinical symptoms were progressive headache (78.6%), and visual dis-turbance (50.0%). After surgical intervention, symptoms disappeared in 74.2% of the patients.

並列關鍵字

nonfunctioning pituitary adenoma ； immunohistochemistry ； alphs-subunit