Flow Cytometric DNA Analysis of Advanced Prostatic Adenocarcinoma

以去氧核糖核酸流動細胞計數法分析侵犯性前列腺癌

吳文正(Wen-Jeng Wu) ； 黃明賢(Ming-Shyan Huang) ； 王慧姬(Huey-Ji Wnag) ； 江博暉(Po-Hui Chiang) ； 黃俊雄(Chun-Hsiung Huang) ； 江金培(Chin-Pei Chiang)

《The Kaohsiung Journal of Medical Sciences》 9卷3期 (1993/03) Pp. 122-130

https://doi.org/10.6452/KJMS.199303.0122

摘要

以去氧核糖核酸流動細胞計數法分析32位侵犯性前列腺癌患者的手術切除標本，結果顯示：去氧核糖核酸成套數者佔61%，而非成套數者佔39%。分析病患預後發現，臨床分期與存活長短最具相關，而病理分級和去氧核糖核酸套數型僅呈相關趨勢。鎮過，若又就轉移性癌分析，則顯示去氧核糖充酸套數型式和存活預後呈有意義的相關。此結果表示，以去氧核糖核酸流動細胞計數法來分析侵犯性前列腺癌患者首次手術標本的染色體套數，對病患存活預測僅具加成效果，尚無法完全取代傳統的病理分級與臨床分期，尤其是對手術後又接受進一步荷爾蒙治療者。

並列摘要

Thirty-two patients with extracapsular invasive prostatic adenocarcinoma were analysed to investigayte the prognostic significance of DNA flow cytometry by suing the nuclear material extracted from paraffin embedded prostatectomy specimens. The DNA ploid patternwas diploid in 61% of the tumors and aneuploid in 39%. A significant correlation between the DNA diploid pattern with pathologic low grade tumors and the DNA aneuploid patten with high stage tumors was not proved. The clinical stage correlated well with patients survival but only DNA ploidy pattern and pathologic grade had trends of correlation. However, if only the stage D tumors were analysed, a significant prognostic predictive value of DNA flow cytometry was identified. Although the results maybe regarded as preliminary, (in view of the small number of patients), these suggest that DNA content from the initial surgical samples provide only a synergisitic effect to the advanced prostate cancers especially for those who underwent hormonal therapy postoperatively.

並列關鍵字

DNA flow cytometry ； advanced prostate cancer