初生大花鼠經麩氨酸鈉處理後對性氣味吸引與追求行為的影響

麩氨酸鈉（monosodium glutamate, MSG）的神經毒性會造成中樞神經系統特定區域和內分泌功能損害的研究已相當透徹。經麩氨酸處理的老鼠被發現生長遲緩、身體肥胖、且性交配行為降低。本實驗即進一層評估麩氨酸鈉對性行為有關之性氣味吸引力（sex-odor attractivity）與追求（approach）能力之影響，以此多方面探討麩氨酸造成老鼠之性交配能力降低的可能原因。此實係將出生後第一及繳三日之大花鼠（Long-Evans rats）以皮下注射麩氨酸生理食鹽溶液（400mg MSG/ml normal saline/0.1 kg B. W.），而對照組則以等量之生理食鹽水投與之（1 ml/0.1 kg B.W.）, 於三個月大後，觀察其性氣味吸引力與追求行為。其結果顯示經麩氨酸鈉處理之大花鼠：(1)吸引異性的性氣味吸引力減弱；(2)本身主動追求的能力降低。由本實驗與以往之實驗結果，我們認為麩氨酸減了大花鼠之性氣味吸引力與追求能力，其主要原因可能與周邊激素減少有密切關係，且性氣味吸引力及追求能力之減弱可以解釋麩氨酸處理鼠的交配能力低減之部份原因。

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並列摘要

The neurotoxic effects of monosodium glutamate (MSG) on certain parts of the central nervous system (CNS) and endocrine functions are well documented. MSG-treated rats exhibit stunted growth, obesity and decrease in sexual behavior. The present study was designed to evaluate how neonatal administration of MSG affects sex-odor attractivity and approach behavior, and to investigate factors limiting copulation in MSG-treated rats. In this experiment, subcutaneous injections of MSG (400mg MSG/ml normal saline/0.1 Kg B.W.) were given to Long-Evans pups on days 1 and 3 after birth, whereas the control groups received normal saline injections of equal volume (1ml/0.1 kg B.W.). When the rats were 3 months old, sex-odor attractivity and approach behavior were tested. Two points were displayed by MSG-treated rats: (a) attenuated the attractivity of sex-odor. (b) decreased performance of sexual approach to partners. From our results and those of a previous study , we suggest that the deterioration of sex-odor attractivity and approach behavior to partners is attributed to a decline in sexual hormones. Furthermore, we concluded that this decrease in behaviors is to some extent responsible for reduced copulatory behavior.

並列關鍵字

monosodium glutamate ； sex-oder ； approach

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初生大花鼠經麩氨酸鈉處理後對性氣味吸引與追求行為的影響

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