- 期刊
Holoprosencephaly and Trisomy 13 in a Fetus with Maternal Early Gestational Amphetamine Abuse - A Case Report
妊娠初期孕婦濫用安非他命，合併胎兒全前腦症和第13號三染色體症的一個病例報告
摘要
經產前超音波及核磁共震掃措，在妊娠26週診斷出一例先天異常：全前腦症兒，且羊水穿刺檢查出有染色體異常(第13號三染色體症)。引產後病理報告解剖證實全前腦症之診斷。胎兒外觀，只有一鼻樑而無鼻孔，右側腳趾有六個。同時，母親為安非他命成癮者，吸食時間為一年半，且在妊娠第一期仍有吸食。安非他命在動物已被證實有致畸胎性，在人類臨床報告仍然缺乏，此報告則為全前腦症，第13號三染色體症合併母體於妊娠初期之安非他命濫用的病例報告。
關鍵字
無資料並列摘要
We report a congenital anomalous fetus with holoprosencephaly, prenatally diagnosed by sonography and MR scan at the twenty-sixth week during the gestational period. Chromosome analysis by amniocentesis revealed trisomy 13 (47,XY, +13). The diagnosis was confirmed by autopsy. After induction, external examination showed a proboscis-like nose on the normal nose position. The right foot showed polydactylia with wide separation of the fifth and sixth toes. We found that the mother was an abuser of amphetamine at an early gestational age. The teratogenic effect of D-amphetamine on animals has been noted, but no previous clinical case of a congenital anomalous fetus and maternal abuse of amphetamine has been reported. This case report is the first to reveal holoprosencephaly and trisomy 13, with maternal early gestational abuse of amphetamine.
延伸閱讀
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