Comparison of Intravenous Ipyridamole and Adenosine Tc-99m MIBI Myocardial Imaging For Detection of Ccoronary Artery Disease

比較靜脈注射dipyridamole和adenosine Tc-99m MIBI心肌造影對冠狀動脈疾病之診斷

楊朝欽(Chao-Chin Yang) ； 鍾相彬(Shiang-Bin Jong) ； 陳毓雯(U-Wen Chen) ； 李碧芳(Bi-Fang Lee) ； 吳勝男(Cheng-Nan Wu)

《The Kaohsiung Journal of Medical Sciences》 10卷2期 (1994/02) Pp. 68-76

https://doi.org/10.6452/KJMS.199402.0068

摘要

A total of 44 patients referred for Tc-99m MIBI myocardial imaging for detection of coronary artery disease (CAD) were studied to compare the differences in heart beat, blood pressure, electrocardiographic changes and side effects during intravenous infusion of dipyridamole (ID) and adenosine (IA) and also to determine the degree of concordance between ID and IA Tc-99m MIBI imaging. These patients were divided into two groups: 20 suspected CAD patients constituted group I and 24 proven CAD patients formed group II. All patients received ID 0.56 mg/kg for 4 mm and within about 10 days IA 0.14 ig/kg/min for 6 mm with Tc-99m MIBI imaging. The results revealed that maximal heart beat increased and maximal systolic blood pressure decreased in both IA and ID patients with no statistically significant differences. Transient second- degree AV block occurred with IA in 3 patients. Side effects, such as, chest pain, headache, dizziness and shortness of breath occurred more often and were in general more intense in IA patients, but they were typically mild and resolved spontaneously within 1 or 2 mm of discontinuation of IA. Both IA and ID Tc-99m MIBI imaging were normal in 18 of 20 group I patients and were concordant for the presence of perfusion defects in the other 2 patients. Of 24 group II patients, all had myocardial perfusion defects on both tests and were concordant for the severity of the perfusion abnormalities. However, in one patient each, IA and ID Tc-99m MIBI imaging were preferred over the other. In conclusion, both IA and ID Tc-99m MIBI myocardial imaging show good agreement for evaluation of CAD.

並列摘要

A total of 44 patients referred for Tc-99m MIBI myocardial imaging for detection of coronary artery disease (CAD) were studied to compare the differences in heart beat, blood pressure, electrocardiographic changes and side effects during intravenous infusion of dipyridamole (ID) and adenosine (IA) and also to determine the degree of concordance between ID and IA Tc-99m MIBI imaging. These patients were divided into two groups: 20 suspected CAD patients constituted group I and 24 proven CAD patients formed group II. All patients received ID 0.56 mg/kg for 4 mm and within about 10 days IA 0.14 ig/kg/min for 6 mm with Tc-99m MIBI imaging. The results revealed that maximal heart beat increased and maximal systolic blood pressure decreased in both IA and ID patients with no statistically significant differences. Transient second- degree AV block occurred with IA in 3 patients. Side effects, such as, chest pain, headache, dizziness and shortness of breath occurred more often and were in general more intense in IA patients, but they were typically mild and resolved spontaneously within 1 or 2 mm of discontinuation of IA. Both IA and ID Tc-99m MIBI imaging were normal in 18 of 20 group I patients and were concordant for the presence of perfusion defects in the other 2 patients. Of 24 group II patients, all had myocardial perfusion defects on both tests and were concordant for the severity of the perfusion abnormalities. However, in one patient each, IA and ID Tc-99m MIBI imaging were preferred over the other. In conclusion, both IA and ID Tc-99m MIBI myocardial imaging show good agreement for evaluation of CAD.

並列關鍵字

Intravenous dipyridamole ； intravenous adenosine ； Tc-99m MIBI myocardial imaging