汗斑病人皮膚生理免疫病理狀態之探討

Study on Cutaneous Physio-Immuno-Pathological Status in Tinea Versicolor

方甘棠(Kan-Tang Fang)

《The Kaohsiung Journal of Medical Sciences》 10卷4期 (1994/04) Pp. 210-216

https://doi.org/10.6452/KJMS.199404.0210

摘要

吾人以汗斑（tinea versicolor）之患者20名並另以健康成人20名做為對照組研究，藉以探討病人皮膚生理、免疫、病理之異動情形，發現皮膚之皮脂腺分泌量、角質層含水量減少，唯表皮pH值較正常者高，而角質層層數、Filaggrin、Involucrin 與正常者無異。表皮酸性被膜（acid mantle）受到破壞，原因可能為汗腺分泌量旺盛，黴菌侵蝕角質層中之胺基酸（amino acid）及脂防。而皮脂腺分泌量減少，可能因黴菌以角質層中之胺基酸及脂肪為營養將其消耗所致。病變處表皮內可見IL-lα呈弱陽性反應，顯示表皮受到黴菌刺激呈現免疫亢進現象。

並列摘要

This study examined 20 cases of tinea versicolor to assess the dermato-physiological, immunological and pathological status of lesion sites as compared to 20 normal control subjects. Lesion sites showed a significant decrease in Sebaceous gland secretions and water content and an increase in pH value compared to normal skin. There was no significant change in involucrin, filaggrin, or number of stratum corneum cell layers. However, lesions showed weak positive staining of IL-1α. A possible mechanism for these changes is that profuse sweat gland secretions predispose to fungal growth and acid mantle destruction, with the pathogens consuming amino acids and sebum as nutrients. Slight increases in IL-1α levels seen in infected areas could be due to a fungus-stimulated immune reaction in the stratum corneum.

並列關鍵字

Tinea versicolor ； skin physiology ； IL-1α