Study on Some Biological and Antigenic Characteristics of CA24v Isolates in Taiwan in 1985-1989

1985-1989年間CA24v台灣病毒分離株之生物學及抗原特性研究

林貴香(Kuei-Hsiang Lin) ； 許明木(Min-Muh Sheu) ； 王姮臨(Heng-Lin Wang) ； 黃文龍(Wen-Loong Huang) ； 陳振武(Chen-Wu Chen) ； 楊照雄(Czau-Siung Yang)

《The Kaohsiung Journal of Medical Sciences》 10卷6期 (1994/06) Pp. 279-286

https://doi.org/10.6452/KJMS.199406.0279

摘要

由柯沙奇病毒24型變異株，所引起的急性出血性結膜炎（AHC）於1985年首次登陸台灣先後於1985-1986年，1988-1989年發生兩次大流行。為了解這兩大流行中，病毒分離株彼此間之生物學及抗原特性之關係，吾人由兩大流行中選取四株病毒L077/85，V116/86，590/88，722/89與原型株EH24/70一同進行生物學及抗原特性之研究。將此四株病毒及原型株EH24/70免疫動物並以交叉中和試驗、動力中和試驗、溶斑試驗及蛋白質分析研究其彼此間的關係。結果顯示1985-1989年分離的四病毒株彼此間無明顯的差異，但1985-1989年分離的四病毒株與原型株EH24/70間卻有明顯的差異。

並列摘要

In order to understand the relationship between the CA24v isolates which caused two epidemics of acute hemorrhagic conjunctivitis (AHC) in 1985-1986 and 1988-1989 in Taiwan, biological and antigenic characteristics were studied with four CA24v strains, L077/85, V116/86, 590/88 and 722/89, which were isolated during the epidemics. The prototype strain, EH24/70, was used for comparison. In terms of cross neutralization, kinetic neutralization, plaque assay and protein electrophoresis, no obvious differences were found between the isolates from the two epidemics though differences were found between these isolates and the prototype.

並列關鍵字

Acute hemorrhagic conjunctivitis ； Cross neutralization test ； Kinetic neutralization test