Existence of a Well-Defined Pulmonary Lesion on Plain Chest Film Predicts Poor Response of Chemotherapy in Small Cell Lung Cancer

若由胸部X 光片上可找到一界限清楚之病灶則可預估此型小細胞肺癌對於化學治療之反應較差

沈光漢(Gwan-Han Shen) ； 林增熙(Tzeng-Hsi Lin) ； 徐武輝(Wu-Huei Hsu) ； 江自得(Chi-Der Chiang)

《The Kaohsiung Journal of Medical Sciences》 11卷3期 (1995/03) Pp. 133-141

https://doi.org/10.6452/KJMS.199503.0133

摘要

Background: Plain chest film is the most convenient and common tool used to evaluate the reponse of lung cancer to chemotherapy. Many authors tried to evaluate the use of plain chest films to predict chemotherapy response. This study investigated a new factor which could be used to predict the chemotherapy response of small cell lung cancer (SCLC).
Methods: Sixty-two patients with cytopathologically proven small cell lung cancer receiving at least two courses of chemotherapy were included in this study. Among these patients, thirty-nine patients received six courses of chemotherapy. The regimens of chemotherapy are Etoposide (100 mg/rn2) and Cisplatin (25 mg/rn2). We divided these patients into two groups according to whether a well-defined pulmonary lesion excluding hilar and mediastinal lymphoadenopathy, could be identified on plain chest X-ray (CXR). Group I consisted of 31 patients with identified lesions on the CXR; group II consisted of 31 patients with unidentifiable lung lesions. CXRs were taken each time before chemotherapy and were collected and compared to evaluate the chemotherapy reponse. The 39 patients receiving six course of chemotherapy, were further divided into group I (n19) and group II (n20) to evaluate the chemotherapy response.
Results: After two courses of chemotherapy, we found 23 patients 174.2% (23/31)1 in group I had partial response(PR) as compared to 12 patients 138.7% (12/31)1 in group II (P ＜0.05). For the 39 patients receiving six courses of chemotherapy, we could find only five patients 116.1% (5/19)1 in group I who had a compete response (CR) as compared to 17 patients 185% (17/20)1 in group II (P＜0.001).
Conclusion: For patients with SCLC, a well-defined lung lesion on a CXR could be an important new factor to predict the chemotherapy response. It could predict less responsiveness to chemotherapy.

並列摘要

Background: Plain chest film is the most convenient and common tool used to evaluate the reponse of lung cancer to chemotherapy. Many authors tried to evaluate the use of plain chest films to predict chemotherapy response. This study investigated a new factor which could be used to predict the chemotherapy response of small cell lung cancer (SCLC).
Methods: Sixty-two patients with cytopathologically proven small cell lung cancer receiving at least two courses of chemotherapy were included in this study. Among these patients, thirty-nine patients received six courses of chemotherapy. The regimens of chemotherapy are Etoposide (100 mg/rn2) and Cisplatin (25 mg/rn2). We divided these patients into two groups according to whether a well-defined pulmonary lesion excluding hilar and mediastinal lymphoadenopathy, could be identified on plain chest X-ray (CXR). Group I consisted of 31 patients with identified lesions on the CXR; group II consisted of 31 patients with unidentifiable lung lesions. CXRs were taken each time before chemotherapy and were collected and compared to evaluate the chemotherapy reponse. The 39 patients receiving six course of chemotherapy, were further divided into group I (n19) and group II (n20) to evaluate the chemotherapy response.
Results: After two courses of chemotherapy, we found 23 patients 174.2% (23/31)1 in group I had partial response(PR) as compared to 12 patients 138.7% (12/31)1 in group II (P ＜0.05). For the 39 patients receiving six courses of chemotherapy, we could find only five patients 116.1% (5/19)1 in group I who had a compete response (CR) as compared to 17 patients 185% (17/20)1 in group II (P＜0.001).
Conclusion: For patients with SCLC, a well-defined lung lesion on a CXR could be an important new factor to predict the chemotherapy response. It could predict less responsiveness to chemotherapy.

並列關鍵字

small cell lung cancer (SCLC) ； chest X-ray (CXR) ； chemotherapy