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Diagnosis of Prostatic Intraepithelial Neoplasia in Whole Mount Sections of Prostates

前列腺全載切片之上皮內贅瘤之診斷

摘要


前列腺之異形增生或稱上皮內贅瘤,在老年男性相當常見,並與前列腺腺癌有關。臨床懷疑腫瘤時,如果在切片上又發現高等級之前列腺上皮內贅瘤,須進一步探查惡性腫瘤之存在。 本研究在48例前列腺全載切片中找出前列腺上皮內贅瘤並予以分級。同時也研究其他病灶,如萎縮、腺體增生、基底細胞增生,以及貯精囊上皮之形態。其中36例因前列腺腺癌切除之前列腺全部含有上皮內贅瘤。前列腺上皮內贅瘤、萎縮、腺體增生、基底細胞增生,與貯精囊上皮等之鑑別診斷在全載切片上相當容易。前列腺全載切片為病理醫師之珍貴教材。

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並列摘要


Dysplasia of prostate or prostatic intraepithelial neoplasia (PIN) is associated with prostatic adenocarcinoma, which is quite common in elderly males. The presence of high grade PIN in biopsy of patients with clinically suspicious tumors is an indication of further search for malignancy. Whole mount sections of 48 prostates were studied. PIN was sought and graded. The morphology of other lesions including atrophy, adenosis and basal cell hyperplasia, and also seminal vesicle epithelium was studied. All 36 prostates resected for treatment of prostatic adenocarcinoma contained foci of PIN. The differential diagnosis of PIN, atrophy, adenosis, basal cell hyperplasia and seminal vesicle epithelium is quite easy when whole mount sections are studied. Whole mount sections of prostates are valuable teaching material for pathologists.

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