非胰島素依賴型糖尿病合併胃運動功能障礙

Gastric Emptying in Non-Insulin Dependent Diabetic Patients

楊勝舜(Sheng-Shun Yang) ； 黃志焜(Chih-Kuen Huang) ； 陳儉鏗(Gran-Hum Chen) ； 高嘉鴻(Chia-Hung Kao) ； 張繼森(Chi-Sen Chang)

《The Kaohsiung Journal of Medical Sciences》 12卷6期 (1996/06) Pp. 311-316

https://doi.org/10.6452/KJMS.199606.0311

摘要

本研究係採用放射性核種（500μCi Tc-99m phytate）胃排空時間的方法評估非胰島素依賴型糖尿病人的胃運動功能。我們總共收集了74例男性非胰島素依賴型糖尿病之病例，另外以46例健康成人為對照組。結果顯示非胰島素依賴型糖尿病人固態胃排空時間（149.44±64.0分鐘）比對照組（88.7±14.2分鐘）明顯延長，74例糖尿病人中有53例固態胃排空延長，占71.6 %；而液態胃排空時間（38.7±35.3分鐘）則與對照組（46.2±11.1分鐘）與顯著的差異；其中糖尿病人血糖控制是否良好、糖尿病病程長短、有無臨床症狀與因、液態胃排空時間並無顯著相關性。闡明胃運動功能障礙確實是非胰島素依賴型糖尿病人相當普遍的現象，血糖拉制情形、糖尿病病程及上消化道症狀無法預估胃排空是否延長；而放射性核種胃排空時間的測定是一種安全且簡易的檢驗工具，有重要的臨床診斷價值。

並列摘要

Disordered gastrointestinal motility is an often overlooked clinical problem. Delayed gastric emptying of solid and/or liquid meal in patients with both type 1 and type 2 diabetes mellitus occurs in approximately 50% of these patients. Gastric emptying time (GET) was studied in seventy four non-insulin dependent (type 2) diabetic out-patients by using radionuclide gamma-photography with Tc-99m phytate solid experimental meal. Thirty nine of them received Tc-99m phytate liquid test meal on the next day. Forty six normal healthy volunteers acted as controls. The results showed that solid GET in patients with type 2 diabetes mellitus was significantly delayed (149.44±64.0 mm) as compared with that in the control group (88.7±14.2 mm) (p＜0.00l). Fifty three among theDivison se 74 diabetic patients had delayed solid GET, accounting for 71.6%. Only 5 of 39 (12.8%) diabetic patients showed delayed liquid GET (average 38.7±35.3 mm; control 46.2±11.1 mm). There were no differences in sugar control, duration of the disease, and upper gastrointestinal symptoms between patients with delayed GET and those with normal GET. We concluded that delayed gastric emptying is very common in patients with non-insulin dependent diabetes mellitus and which has no direct correlation to blood sugar control, duration of the disease, and upper gastrointestinal symptoms. Radionuclide solid gastric emptying test is a both safe (low radioactivity) and convenient (non-invasive) diagnostic tool in non-insulin dependent diabetic gastroparesis.

並列關鍵字

non-insulin dependent diabetes mellitus ； gastric emptying ； upper gastrointes-tinal symptoms