The Status of Serum Hepatitis B Virus Dna in Hbsag - Positive Hepatocellular Carcinoma

B型肝炎表面抗原陽性肝細胞癌病患血清中B型肝炎病毒去氧核醣核酸之分析

余明隆(Ming-Lung Yu) ； 莊萬龍(wan-Long Chuang) ； 周德源(Teh-Yuan Chow) ； 陳信成(Shinn-Cherng Chen) ； 盧勝男(Sheng-Nan Lu) ； 林子堯(Zu-Yau Lin) ； 謝明裕(Ming-Yuh Hsieh) ； 王良彥(Liang-Yen wang) ； 張文宇(Wen-Yu Chang)

《The Kaohsiung Journal of Medical Sciences》 12卷8期 (1996/08) Pp. 466-470

https://doi.org/10.6452/KJMS.199608.0466

摘要

為闡明B型肝炎表面抗原陽性肝細胞癌病患血清中B型肝炎病毒去氧核醣核酸(HBC DNA)存在之狀況，100位B型肝炎表面抗原陽性慢性肝臟疾病病患及19位B型肝炎很面抗原陽性肝細胊癌病患接受研究分析。
結果發現：e抗原陽性慢性肝臟疾病病患血清中HBV DNA陽性率較e抗原陰性慢性肝臟疾病病患之HBV DNA陽性率為有意義之增高。而在慢性肝臟疾病病患中，血清中HBV DNA之存在與病患之年齡呈負相關。相反的，肝細胞癌病患血清中之HBV DNA陽性率與e抗原存在與否及年齡均無有意義之相關，且e抗原陰性肝細胞癌病患血清中之HBVC DNA陽性率較e抗原陰性慢性肝臟疾病病患之HBV DNA陽性率亦為有意義之增高。然而肝細胞癌病患血清中HBV DNA之濃度較慢性肝臟疾病病患血清中之濃度為有意義之降低。
由以上結果推論：(1)肝細胞癌病患體內B型肝炎病毒之複製狀況與慢性肝臟疾病病患體內不同；(2)持續而低濃度之B型肝炎病毒之複製可能與肝細胞癌存在及出現有關。

並列摘要

To elucidate the status of serum hepatitis B virus (HBV) DNA in HBsAg-positive hepatocelular carcinoma (HCC), 100 type B chronic liver disease (CLSD) patients and 19 HCC patients were studied. The positive rate of serum HBV DNA in HBeAg-posi-tive CLD patients was significantly higher than that in HBeAg-negative CLD patients, and the correlation between the presence of serum HBV DNA and patients age showed a negative trend. In contrast, the positive rates of serum HBV DNA in HCC patients were not related to the status of HBeAg and age, and the positive rate of serum HBV DNA in HBeAg-negative HCC patients was significantly higher than that in HBeAg-negative CLD patients. Nevertheless, the serum concentrations of HBV DNA in HCC patients were significantly lower than those in CLD patients. These results suggest that replication of HBV in HCC patients might differ from that in CLD patients, and that replication of HBV in HCC patients might differ from that in CLD patients, and that persistent low-level HBV replication might be related to the presence of HCC.

並列關鍵字

hepatitis B virus ； hepatocellular carcinoma ； chronic liver disease