- 期刊
The Genotypes of Hepatitis C Virus in Patients with Chronic Hepatitis C Virus nfection in Southern Taiwan
南台灣慢性C型肝炎病人之C型肝炎病毒基因型的研究
摘要
To ivestigate the genotype distribution of hepatitis C virus (HCV) in southern Taiwan, the sera from 56 patients with chronic HCV infection were studied. Twenty-nine patients were men and 27 were women. Age ranged from 22 to 65 years (mean, 47.3± 11.4). Eighteen of them had chronic persistent hepatitis, 27 had chronic active hepatitis, and 11 had liver cirrhosis. HCV RNA was detected by reverse transcription-nested polymerase chain reaction using primers derived from the 5¡¦-noncoding region. The genotypes of HCV were determined by amplification of the core region with the type-specific primers as described by Okamoto et a1.. All sera were positive for HCV RNA. The prevalence rates of genotypes were as follows: lb/Il, 44.6%(25/56); 2a/ III, 41.1%(23/56); 2b/ 1V, 3.6%(2/56); mixed 1b/ II + 2a/ III, 5.4%(3156): mixed lb/ II + 2b/ 1V, 1.8%(1/56) and type unclassified 3.6%(2/56). The distribution of genotypes was not related to the patients¡¦ age, sex, and histological changes. Nevertheless, patients having past history of blood transfusion had a significantly higher rate of HCV type 2a/ Ill infection (72.2% versus 34.2%, p ＜.05, chi-square test). We concluded that both of the HCV genotypes 1 bill and 2ai Ill are predominant types in southern Taiwan and regional HCV genotype distribution may differ even within this island. Selective transmission of specific genotypes may pass along different infectious routes.
關鍵字
無資料並列摘要
To ivestigate the genotype distribution of hepatitis C virus (HCV) in southern Taiwan, the sera from 56 patients with chronic HCV infection were studied. Twenty-nine patients were men and 27 were women. Age ranged from 22 to 65 years (mean, 47.3± 11.4). Eighteen of them had chronic persistent hepatitis, 27 had chronic active hepatitis, and 11 had liver cirrhosis. HCV RNA was detected by reverse transcription-nested polymerase chain reaction using primers derived from the 5¡¦-noncoding region. The genotypes of HCV were determined by amplification of the core region with the type-specific primers as described by Okamoto et a1.. All sera were positive for HCV RNA. The prevalence rates of genotypes were as follows: lb/Il, 44.6%(25/56); 2a/ III, 41.1%(23/56); 2b/ 1V, 3.6%(2/56); mixed 1b/ II + 2a/ III, 5.4%(3156): mixed lb/ II + 2b/ 1V, 1.8%(1/56) and type unclassified 3.6%(2/56). The distribution of genotypes was not related to the patients¡¦ age, sex, and histological changes. Nevertheless, patients having past history of blood transfusion had a significantly higher rate of HCV type 2a/ Ill infection (72.2% versus 34.2%, p ＜.05, chi-square test). We concluded that both of the HCV genotypes 1 bill and 2ai Ill are predominant types in southern Taiwan and regional HCV genotype distribution may differ even within this island. Selective transmission of specific genotypes may pass along different infectious routes.
延伸閱讀
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