- 期刊
Clinical Experiences of Germ Cell Tumor in Cryptorchid Testis
隱睪症併發睪丸生殖細胞癌的治療經驗
摘要
隱睪症是男性先天異常的疾病，也是併發睪丸腫瘤的危險因子；特別位於腹內的隱睪發生腫瘤時，與陰囊內的睪丸腫瘤有所不同，其腫瘤大小非到一定程度，不易被察覺。在本研究中，我們回溯性的分析隱睪症併發睪丸生殖細胞癌的病例，以探討其診斷、治療方法及預後。這些回溯性的研究，包括1973年2月至1996年12月間，於本院診治的11例隱睪症併發睪丸生殖細胞的病例，其中3例的隱睪症是位於鼠蹊部，8例是位於腹內；第I病期4例，第II病期4例，第III病期3例。追蹤期間，最短是1個月，最長是163個月。病患年齡，最小是22歲，最大是80歲（平均是47.6歲）。其組織病理診斷為精原細胞癌9例，非精原細胞癌2例。位於鼠蹊部的睪丸切除術與放射線治，第III病期的1例採用睪丸切除術與化學治療；8例位於腹內的睪丸生殖細胞癌病例，則接受集中聯合療法，其中包括睪丸切除術，放射線治療，化學治療等，在追蹤期間，第III病期的2例死亡，目前存活9例，存活率是81.8％。
關鍵字
無資料並列摘要
The increased risk of malignancy occurring in the cryptorchid testis is well established. In order to investigate the management and outcome of germ cell tumor in cryptorchid testis, we retrospectively rewiewed the records of 11 patients with cryptorchid tumor treated at our hospital between January 1973 and December 1996. Mean patient age at diagnosis was 47.6 years (range, 22-80). Of these patients, 3 were found in the inguinal area and 8 in the abdomen. Six occurred in the right cryptorchid testis and 5 in the left. Four patients presented with stage I disease, 4 with stage II, and 3 with stage III. Median follow-up period was 48.0 months (range 1-163). All 3 inguinal cryptorchid tumors and 6 of 8 abdominal cryptorchid tumors were seminoma. The remaining 2 abdominal cryptorchid tumors were nonseminomatous germ cell tumor. Of the 3 patients with inguinal cryptorchid seminomas, 2 with stage I disease were treated with prophylactic radiotherapy to nodal areas and 1 with stage III disease was treated with chemotherapy. Eight patients with abdominal cryptorchid tumors were treated with multidisciplinary approaches, including radiotherapy, cisplatinbased combination chemotherapy, and surgery. The overall survival rate for patients with inguinal and abdominal cryptorchid tumor was 81.8%. Two patients with stage III disease died during treatment and the remaining 9 patients are still alive without evidence of disease
延伸閱讀
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