The DCC Protein Expression in Breast Carcinoma

DCC蛋白在乳癌之表達

許永祥(Yung-Hsiang Hsu) ； 蕭正光(Cheng-Kuang Shaw)

《The Kaohsiung Journal of Medical Sciences》 16卷5期 (2000/05) Pp. 233-240

https://doi.org/10.6452/KJMS.200005.0233

摘要

DCC基因位於第十八對染色體上，此基因不活化與大腸直腸癌之發生與轉移有關。本研究，用免疫組織化學染色方法觀察79例侵襲性乳癌細胞內 DCC蛋白， P53及HER-2/neu之表達。DCC蛋白表達減少者有42例(52%)，而HER-2/neu及P53 過度表現率分別為36.8% (29/79)及32.9% (26/79)。為了評估病人預後，病人追蹤時間由1990年5月到 1998年8月，平均追蹤52個月( 4-94個月)，病人同時合併DCC陰性及HER-2/neu過度表現對乳癌預後有邊緣效應(P=0.060)。但病人同時合併DCC陰性及P53過度表現則對乳癌預後無影響 (P=0.36 )。本研究顯示同時DCC蛋白表現減少及 HER-2neu過度表現可能影響乳癌預後。

並列摘要

Inactivation of the gene “deleted in colon cancer” (DCC) on chromosome 18 is known to be associated with the tumorigenesis and metastasis of colorectal cancer. In the present study, we investigated the expression of DCC, PS3 and HER-2/neu product in surgical specimens from 79 patients with invasive- breast cancer by immunohistochemistry staining and found the expression of Dee to e decreased in 42 tumors (52%). Overexpression of HER-2/neu and P53 was detected in 29 (36.8%) and 26 (32.9%) of this 79 breast cancer specimens, respectively. To evaluate the outcomes of the 79 breast cancer patients, we followed up the patients during the period from May 1990 to August 1998. The average length of follow-up was 52 months (ranging from 4 to 94 months). Patients with tumors having a combination of DCC-negative and HER-2/neu overexpression showed a marginal influence on survival time of breast cancer (P=0.06). However, patients with tumors having a combination of DCC-neagive and P53 overexpression showed no influence of these on survival time of breast cancer (P=0.36). These findings suggest that a decreased Dee expression and HER-2/neu overexpression may influence the prognosis of breast cancer.

並列關鍵字

DCC；HER-2/neu；P53；breast carcinoma