Clinical Significance of Distribution Patterns of P53 Immunoreactivity in Astrocytic Tumors

p53免疫組織染色型態應用於星狀細胞瘤的臨床意義

黃旭霖(Shiuh-Lin Hwang) ； 洪義人(Yi-Ren Hong) ； 劉安祥(Ann-Shung Lieu) ； 李昆興(Kung-Shing Lee) ； 林靖國(Ching-Kuo Lin) ； 思瑋玓(Wei-Dih Sy) ； 蔡志仁(Chee-Yin Chai) ； 林相如(Hsiang-Ju Lin) ； 黃祖源(Tzuu-Yuan Huang) ； 洪純隆(Shen-Long Howng)

《The Kaohsiung Journal of Medical Sciences》 16卷6期 (2000/06) Pp. 279-284

https://doi.org/10.6452/KJMS.200006.0279

摘要

同級惡性度星狀細胞瘤患者的預後不同，顯示此腫瘤的生物特性因各個腫瘤而異。p53免疫組織染色和腫瘤患者的預後，兩者關係目前仍未釐清。本研究從p53染色型態的觀點分析各級惡性度星狀細胞瘤患者的預後與p53染色型態的關係。p53免疫染色可分為四種型態：陰性，散落性（scattered），局部群集性（focally clustered），廣泛群集性（diffusely clustered）。再依型態特性及陽性細胞數有意義比率（大於或等於5%）可分為二大類：p53陽性染色（局部和廣泛群集性）及p53陰性染色（陰性及散落性）。研究顯示在WHO分類的各級惡性度星狀細胞瘤患者的預後和p53染色型態呈有意義的差別（p=0.0185）。因此，我們認為p53免疫染色型態可作為同級惡性度星狀細胞瘤患者預後之參考指標。

並列摘要

The difference of prognosis in patients with the same WHO grade of astro-cytic tumors suggests that such tumors comprise a heterogeneous group in bio-logical behavior. The correlation between p53 immunoreactivity and prognosis has often been reported but remains controversial. From the perspective of clonal expansion of p53 immunopositive cells, the distribution patterns of p53 immu-noreactivity can be divided into four types: negative, scattered, focally clustered, and diffusely clustered. The survival rate was evaluated by classifying the p53 immunoreactiviy into two groups: the significantly immunopositive patterns （focally and diffusely clustered typs）and the significanly immunonegative pat-terns（negative and scattered types）. The survival analysis showed a highly significant difference between these two patterns within the same WHO grade of astrocytic tumors（p=0.0185）. Our studies demonstrate that the distribution paterns of p53 immunoreactivity, which reflect the trends of clonal expansion of p53 immunopositive cells, are significantly valuable in predicting the prognosis of patients with the same WHO grade of astrocytic tumors.

並列關鍵字

p53 ； immunoreactivity ； astrocytoma ； prognosis