Mutation Analysis of the BCL 10 Gene in Hepatocellular Carcinoma

肝癌之Bcl 10基因的突變分析

葉坤土(Kun-Tu Yeh) ； 王妙媛(Nancy M. Wang) ； 李賢雄(Hsien-Hsiung Lee) ； 張建國(Jan-Gowth Chang)

《The Kaohsiung Journal of Medical Sciences》 16卷7期 (2000/07) Pp. 332-338

https://doi.org/10.6452/KJMS.200007.0332

摘要

Bcl 10基因最近發現與黏膜淋巴組織形成的淋巴癌及其它癌細胞株的變有關。我們檢查了３１個肝癌組織和其鄰近的非癌組織中Bcl 10基因的突變，結果顯示，在肝癌組織中，11.3％的chromosomes有codon 5 GCA→TCA 突變，4.8%的chromosomes 有 codon 8 CTC→CTG突變，及12.9% 的 chromomsomes有codon 213GGA→GAA突變；而這些突變在非肝癌組統及正人中也同樣的變化。我們認為這三種突變與肝癌的形成無關。

並列摘要

The Bcl 10 gene was recently discovered to be involved in the pathogenesis
of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular
carcinomas along with their corresponding non-tumorous tissues by single strand
conformation polymorphism (SSCP) and direct sequencing. The results showed
that 11.3 % chromosomes had codon 5 GCA to TCA mutation, 4.8% chromo.
somes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon
213 GGA to GAA mutation. These mutations were found not only in the hepatoma
tissues but also in paired non-cancerous tissues and the normal population. We
suggest that these three changes are polymorphisms, and there is no relation
ship with the development of hepatocellular carcinoma.

並列關鍵字

Bcl 10； mutation analysis； hepatocellular carcinoma