Familial Breast Cancer in Southern Taiwan

南台灣家族性乳癌

侯明鋒(Ming-Feng Hou) ； 蔡坤寶(Kun-Bow Tsai) ； 范惠美(Hui-Mei Fan) ； 王貞雅(Chen-Ya Wang) ； 林玟君(Wen-Chun Lin) ； 劉景勳(Chiang-Shin Liu) ； 林相如(Hsiang-Ju Lin) ； 蔡志仁(Chee-Yin Chai) ； 李水龍(Steven Shoei-Lung Li) ； 歐陽賦(Fu Ou-Yang) ； 張永源(Yong-)

《The Kaohsiung Journal of Medical Sciences》 16卷8期 (2000/08) Pp. 414-421

https://doi.org/10.6452/KJMS.200008.0414

摘要

The purpose of this study is to evaluate whether there are pathobiologic differences and differences in overall rates survival between familial and non-familial breast cancer patients in Taiwan. A retrospective study was performed evaluating 76 familial breast cancer patients in 69 families, which included two BRCA1 related cases and six BRCA2 related cases. Patients were compared with 425 non-familial sporadic cases. Familial breast cancer patients had similar ages and stages as non-familial patients (mean,46.6 years vs 48.9 years, p=0.306 ). However, the familial breast cancer patients with BRCA1 and BRCA2 related cases presented at lower stages (p=0.034) and younger ages than non-familial patients (mean, 45.1 years vs 48.9 years P=0.042). The occurrence of infiltrating ductal carcinoma and lobular carcinoma in situ was not significantly different in the two groups. Mucinous carcinoma was represented with 6.7% (4/76) and 1.3% (1/76) medullary carcinoma. The overall grade of familial breast cancer, including BRCA1 and BRCA2 related cases in 8 inflitrating ductal carcinoma, was significantly higher than that of controls. The mean follow up was 4.5 years for familial breast cancers. Five- and 10-year overall survival rates were 69% and 61 % for those with a family history, compared with 86%and 64% for those in the control group (p=0.644). There were no statistically significant differences in disease-free survival rates between the two groups at 5 or 10 years (69% vs 78% in 5 years; 48% vs 58% in 10 years) (p=0.862). Despite the younger ages and earlier stages at presentation in familial breast cancer patients with BRCA1 and BRCA2 related cases, the familial breast cancer patients had higher grade patholobilogic characteristics, but similar prognoses when compared with sporadic breast cancer patients. Owing to the limited number of familial cases in this study, more cases and longer follow up are needed.

並列摘要

The purpose of this study is to evaluate whether there are pathobiologic differences and differences in overall rates survival between familial and non-familial breast cancer patients in Taiwan. A retrospective study was performed evaluating 76 familial breast cancer patients in 69 families, which included two BRCA1 related cases and six BRCA2 related cases. Patients were compared with 425 non-familial sporadic cases. Familial breast cancer patients had similar ages and stages as non-familial patients (mean,46.6 years vs 48.9 years, p=0.306 ). However, the familial breast cancer patients with BRCA1 and BRCA2 related cases presented at lower stages (p=0.034) and younger ages than non-familial patients (mean, 45.1 years vs 48.9 years P=0.042). The occurrence of infiltrating ductal carcinoma and lobular carcinoma in situ was not significantly different in the two groups. Mucinous carcinoma was represented with 6.7% (4/76) and 1.3% (1/76) medullary carcinoma. The overall grade of familial breast cancer, including BRCA1 and BRCA2 related cases in 8 inflitrating ductal carcinoma, was significantly higher than that of controls. The mean follow up was 4.5 years for familial breast cancers. Five- and 10-year overall survival rates were 69% and 61 % for those with a family history, compared with 86%and 64% for those in the control group (p=0.644). There were no statistically significant differences in disease-free survival rates between the two groups at 5 or 10 years (69% vs 78% in 5 years; 48% vs 58% in 10 years) (p=0.862). Despite the younger ages and earlier stages at presentation in familial breast cancer patients with BRCA1 and BRCA2 related cases, the familial breast cancer patients had higher grade patholobilogic characteristics, but similar prognoses when compared with sporadic breast cancer patients. Owing to the limited number of familial cases in this study, more cases and longer follow up are needed.

並列關鍵字

familial breast cancer ； BRCA1 ； BRCA2