The Effect of Fluvastatin on Fibrinolytic Factors in Patients with Hypercholesterolemia

Fluvastatin對高血脂病人纖維溶解因子的影響

林宗憲(Tsung-Hsien Lin) ； 黃智興(Chih-Hsin Huang) ； 溫文才(Wen-Chol Voon) ； 顏學偉(Hsueh-Wei Yen) ； 賴秀美(Hsiu-Mei Lai) ； 梁馨月(Hsin-Yueh Liang) ； 盧怡旭(Ye-Hsu Lu) ； 李坤泰(Kun-Tai Lee) ； 李智雄(Chee-Siong Lee) ； 賴文德(Wen-Ter Lai) ； 許勝雄(Sheng-Hs)

《The Kaohsiung Journal of Medical Sciences》 16卷12期 (2000/12) Pp. 600-606

https://doi.org/10.6452/KJMS.200012.0600

摘要

Several studies have shown cardiovascular benefit in treating hypercholesterolemia with HMG-CoA reductase inhibitor. However, in addition to the lowering of cholesterol, the beneficial effects of this inhibitor reflect other pharmaco logical activities. Whether these beneficial effects are partly mediated by changes in fibrinolytic factors remains to be proven, since clinical studies on the effects of HMG-CoA reductase inhibitors on fibrinolytic factors have not yielded consistent results. The purpose of this study was to evaluate the effects of fluvastatin on fibrinolytic factors in hypercholesterolemic patients. After 6 weeks on a lowfat, low-cholesterol diet, 23 outpatients known to have primary, hypercholesterolemia with low density lipoprotein cholesterol (LDL-C)≧130 mg/dl with at least 2 risk factors or fasting LDL-C≧160 mg/dl were selected for the study. Venous blood samples were collected at baseline and at 8 weeks after fluvastatin therapy (40 mg/day) to measure of tissue plasminogen activator (t-P A), plasminogen activators inhibitor-l (P AI-1), fibrinogen, D-dimer and lipid profiie. After 8 weeks of therapy, fluvastatin reduced serum cholesterol by 11 % (261.9 mg/dl vs 233.2 mg/dl, P＜O.O1) and LDL-C by 22% (191.9 mg/dl vs-149.3 mg/dl, P＜O.Ol). , D-dimer was significantly decreased (O.38'ng/L vs 0.28 ng/L, P=O.O2) and tPA, P AI-l and fibrinogen tended to decrease after therapy. Fluvastatin therapy improved fibrinolytic profile; the result of this study may in part explain the benefit - lowering.

並列摘要

Several studies have shown cardiovascular benefit in treating hypercholesterolemia with HMG-CoA reductase inhibitor. However, in addition to the lowering of cholesterol, the beneficial effects of this inhibitor reflect other pharmaco logical activities. Whether these beneficial effects are partly mediated by changes in fibrinolytic factors remains to be proven, since clinical studies on the effects of HMG-CoA reductase inhibitors on fibrinolytic factors have not yielded consistent results. The purpose of this study was to evaluate the effects of fluvastatin on fibrinolytic factors in hypercholesterolemic patients. After 6 weeks on a lowfat, low-cholesterol diet, 23 outpatients known to have primary, hypercholesterolemia with low density lipoprotein cholesterol (LDL-C)≧130 mg/dl with at least 2 risk factors or fasting LDL-C≧160 mg/dl were selected for the study. Venous blood samples were collected at baseline and at 8 weeks after fluvastatin therapy (40 mg/day) to measure of tissue plasminogen activator (t-P A), plasminogen activators inhibitor-l (P AI-1), fibrinogen, D-dimer and lipid profiie. After 8 weeks of therapy, fluvastatin reduced serum cholesterol by 11 % (261.9 mg/dl vs 233.2 mg/dl, P＜O.O1) and LDL-C by 22% (191.9 mg/dl vs-149.3 mg/dl, P＜O.Ol). , D-dimer was significantly decreased (O.38'ng/L vs 0.28 ng/L, P=O.O2) and tPA, P AI-l and fibrinogen tended to decrease after therapy. Fluvastatin therapy improved fibrinolytic profile; the result of this study may in part explain the benefit - lowering.

並列關鍵字

fibrinolysis；statin；hypercholesterolemia