Positive Association of Ankylosing Spondylitis with Homozygous HLA-B2704, but Protection with B2705 in Taiwan Chinese

台灣人僵直性脊椎炎的發病與HLA-B2704同合子有關

施浤彰(Hung-Chang Shih) ； 劉素卿(Su-Ching Liu) ； 張志鵬(Chih-Peng Chang) ； 陳昇明(Johannes Scheng-Ming Tschen) ； 邱心怡(Hsin-Yi Chiu) ； 劉華昌(Hwa-Chang Liu) ； 張建國(Jan-Gowth Chang)

《The Kaohsiung Journal of Medical Sciences》 17卷10期 (2001/10) Pp. 509-516

https://doi.org/10.6452/KJMS.200110.0509

摘要

僵直性脊椎炎是常見的慢性病之一，95%左右的病人為HLA-B27陽性。我們利用PCR-RFLP的方法分析HLA-B27的亞型與僵直性脊椎炎的關係。在738位超過65歲的正常人中，有42位（5.17%）為HLA-B27陽性，其中6位（14.3%）為B2704的同合子，18位（42.9%）為B2704的異配子，2位（4.8%）同時有B2704及B2705， 1位（2.3%）同時有B2704及B2706，2位（4.8%）為B2705的同合子，11位（26.1%）為B2705的異配子，及2位（4.8%）為 B2706的異配子。而在62位僵直性脊椎炎的病人中，37位（59.6%）為B2704的同配子，而25位（40.3%）則為B2704的異配子。由此可知，HLA-B27的帶因率在台灣地區約為5.7%左右，而同合子的B2704與僵直性脊椎炎的發病有關，但B2705可能具有保護作用。

並列摘要

The study was undertaken to determine the effects of HLA-B27 subtypes on susceptibility to ankylosing spondylitis (AS) in Taiwan Chinese, a polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was developed for subtyping of HLA-B27. In this series, there are 62 patients with AS who were tested HLA-B27 positive serologically and 738 normal persons over the age of 65. Among the 738 normal controls, 42 (5.7%) were HLA-B27 positive. There were six (14.3%) homozygous for B2704, 18 (42.9%) heterozygous for B2704, 2 (4.8%) double heterozygous for B2704 and B2705, one (2.3%) double heterozygous for B2704 and B2706, 2 (4.8%) homozygous for B2705, 11 (26.1%) heterozygous for B2705, and 2 (4.8%) heterozygous for B2706. In our patients with AS, 37 (59.7%) were homozygous for B2704 and 25 (40.3%) were heterozygous for B2704. The HLA-B27 carrier rate in Taiwan healthy old persons is estimated at 5.7%. Susceptibility to AS is determined by homozygos-ity for B2704. However, B2705 may be an indicator of protection against AS in Taiwan Chinese.

並列關鍵字

HLA-B27 ； subtypes ； ankylosing spondylitis ； Taiwan