Changes of Coronary Risk Factors after Eradication of Helicobacter Pylori Infection

幽門螺旋桿菌滅菌治療後冠心症危險因子的變化

盧怡旭(Ye-Hsu Lu) ； 顏學偉(Hsueh-Wei Yen) ； 林宗憲(Tsung-Hsien Lin) ； 黃智興(Chih-Hsin Huang) ； 李坤泰(Kun-Tai Lee) ； 王文明(Wen-Ming Wang) ； 吳登強(Deng-Chyang Wu) ； 溫文才(Wen-Chol Voon) ； 賴文德(Wen-Ter Lai) ； 許勝雄(Sheng-Hsiung Sheu)

《The Kaohsiung Journal of Medical Sciences》 18卷6期 (2002/06) Pp. 266-272

https://doi.org/10.6452/KJMS.200206.0266

摘要

先前有關流行病學的研究顯示胃部慢性幽門螺旋桿菌感染與冠狀動脈疾病有關。然而，藉由幽門桿菌滅菌治療來改變冠狀動脈危險因子的研究報告，為數不多且結果分歧。本前瞻性的研究旨在比較空腹血糖、血脂肪及抗凝因子在病患接受滅菌治療前後的變化。結果48位胃部罹患幽門螺旋桿菌的病人，在接受Omeperazole、Amoxicillin、Clarithromycin三合一治療後，上述相關因子包括空腹血糖、總膽固醇、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、三酸甘油脂、Tissue plasminogen inhibitor、Plasminogen activator inhibitor-1、纖維蛋白原、D-dimer並未有明顯改變。因此幽門螺旋桿菌與冠狀動脈疾病的相關性仍有待進一步研究。

並列摘要

Several epidemiological studies have shown a positive correlation between chronic gastric infection with Helicobacter pylori (HP) and coronary artery disease. A number of reports also claimed that there are strong relationships between HP infection and coronary risk factors. However, clinical studies concerning the changes of coronary risk factors after eradication of HP infection are few and contradictory. We conducted a prospective study aiming to compare sugar, lipid and fibrinolytic profiles before HP eradication with those after HP eradication. HP infection was confirmed by endoscope-based examinations and eradicated by a standard OAC (omeperazole- amoxicillin- clarithromycin) regimen. We measured and compared pre- and post-eradication blood sugar, lipid profiles (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride) and fibrinolytic profiles (tissue-plasminogen activator, plasminogen activator inhibitor-I, fibrinogen, and D-dimer levels). Forty-eight patients (male: female, 25:23; mean age, 50.8 ±11.3 years) with gastric DP infection were enrolled in this study. Although HP infection was conrmed to have been successfully eradicated, no significant changes of blood fasting sugar, lipids or fibrinolytic profiles were found in patients after treatment. Coronary risk factors including fasting sugar, lipid and fibrinolytic profiles were not changed after successful HP eradication treatment. The relationship between HP infection and coronary artery disease needs to be clarified.

並列關鍵字

Helicobacter pylori； coronary risk factors； fibrinolysis； lipids