Single Photon Emission Computerized Tomography in Children with Developmental Language Disorder - a Preliminary Report

發展性語言疾患孩童之99mTc-HMP AO腦質灌注攝影發現

李碧芳(Bi-Fang Lee) ； 楊品珍(Pinchen Yang) ； 鐘育志(Yuh-Jyh Jong) ； 徐秀宜(Hsiu-Yi Hsu) ； 陳正宗(Cheng-Chung Chen)

《The Kaohsiung Journal of Medical Sciences》 18卷8期 (2002/08) Pp. 373-378

https://doi.org/10.6452/KJMS.200208.0373

摘要

臨床上對於語言發展遲緩的孩童，若其感官系統正常，無智能障礙，也不屬於自閉症候群時，則診斷為發展性語言疾患。本研究係以99mTc-HMPAO腦質灌注攝影評估11位有”發展性語言疾患”的孩童(平均年齡5歲10個月，範圍4歲2個月 ─ 10歲9個月)；平均非語文智力測驗得智商107，範圍82-137)的大腦血流分布狀況。結果顯示，若將左右兩側對稱區域大腦血流量差異超過10%定義為”顯著差異”時，10位孩童(90.9%)左右大腦的血流分布有顯著差異，所有的小孩均為顳葉有問題(5/11在顳葉外側，4/11在顳葉內側，4/11在顳葉中部)。本研究係少量個案之初期研究，結果顯示，發展性語言疾患可能是大腦語言相關部位產生潛在的神經生物問題所致。

關鍵字

發展性語言疾患 ； 單光子電腦斷層掃描

並列摘要

Developmental language disorder (OLD) is a diagnosis given to a nonautistic child who has inadequate language acquisition despite adequate hearing, sensorimotor, and cognitive skills. We used high-resolution single photon emission computerized tomography (SPECT) with labeled technetium-99m-D, L-hexamethyl-propylene amine oxime (99mTc-HMP AO) to measure regional cerebral blood flow (rCBF) in 11 children with OLD. Their mean age was 5 years 10 months (range, 4 yr 2 mo to 10 yr 9 IDO) and mean nonverbal IQ was 107 (range, 82-137). When inter-hemispheric flow discrepancy was defined as a bilateral rCBF difference of more than 10%, 10 children (90.9%) had discrepant blood flow. Temporal lobes were involved in all 10 children: lateral-temporal in five, medial-temporal in four, and medial-temporal in four. Though the study was small and the results are preliminary, results suggest that OLD may be a consequence of an underlying neurobiologic problem in areas of the brain known to be involved with language.

並列關鍵字

developmental language disorder ； SPECT