- 期刊
Primapy Germ Cell Tumors of Mediastinum: 10 Years of Experience in a Tertiary Teaching Hospital
原發之縱膈腔生殖母細胞瘤－一所醫學中心之十年經驗
摘要
生殖母細胞瘤(germ cell tumors)絕大部份原發於生殖腺，少數會有原發於生殖腺外，其中以縱膈腔內為常見，大多是在前縱膈腔。發生年齡層以年輕人居多。生殖母細胞瘤包括最常見的畸胎瘤(teratoma)及惡性非畸胎瘤(non-teratomatous tumors)－包含了精母細胞瘤(seminoma)及惡性非精母細胞瘤(non-seminomatous tumors)，後者又包含了卵黃囊瘤(yolk sac tumor)、絨毛膜瘤(choriocarcinoma)、胎芽性癌(embryonic carcinoma)及混合型(mixed type)。只有極少數原發性惡性縱膈腔非精母細胞瘤被報告過。本文回顧十年來高雄醫學大學附設醫院所有原發於縱膈腔之生殖母細胞瘤－共有畸胎瘤十一例，精母細胞瘤一例，卵黃囊瘤兩例，討論其臨床表徵、細胞型態、治療方式及預後。
並列摘要
Germ cell tumors occur mostly in the gonad. Extragonadal germ cell tumors are rare, and most occur in the retroperitoneum and mediastinum. Primary mediastinal germ cell tumors are often found in the anterior portion of the mediastinum and include teratomas and non-teratomatous tumors. Non-teratomatous tumors include seminomas and malignant non-seminomatous germ cell tumors (MNSGCTs). MNSGCTs include yolk sac tumors, choriocarcinomas, embryonal carcinomas, and mixed type germ cell tumors. Teratomas are the most common germ cell tumors of the mediastinum, and seminomas are the most common non-teratomatous germ cell tumors of the mediastinum. Cases of primary mediastinal MNSGCT reported in the literature are rare. In this report, we review all primary mediastinal germ cell tumors from a 10-year period at the Chung-Ho Memorial Hospital of Kaohsiung Medical University. A total of 14 cases were reviewed, including 11 patients with mature teratomas, two with yolk sac tumors, and one with seminoma. We discuss the differences in clinical presentation, histopathologic characteristics, treatment, and prognosis.
延伸閱讀
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