Association of Apolipoprotein E Polymorphism with Ischemic Stroke Subtypes in Taiwan

台灣之Apolipoprotein E基因多形性與缺血性腦中風類型之相關性研究

賴秋蓮(Chiou-Lian Lai) ； 劉景寬(Ching-Kuan Liu) ； 林瑞泰(Ruey-Tay Lin) ； 戴志達(Chih-Ta Tai)

《The Kaohsiung Journal of Medical Sciences》 23卷10期 (2007/10) Pp. 491-497

摘要

本研究之目的是探討在台灣apolipoprotein E (APOE)基因多形性與缺血性腦中風類型之相關性。我們採用cerebrovascular disease Ⅲ之分類，徵召143位腔隙型缺血性腦中風患者，114位粥狀梗塞型缺血性腦中風患者，及112位正常人。利用血掖中之白血球，作APOE基因多形性分析。結果發現，腔隙型缺血性腦中風患者具ε3/ε4之比率呈現有意義的差別。但在粥狀梗塞型缺血性腦中風患者不論是基因型或其對偶基因分佈，都無顯著差異。本研究結果顯示ε3/ε4之基因型可能與腔隙型缺血性腦中風有關，而粥狀梗塞型缺血性腦中風則否。因此我們認為，對罹患腔隙型缺血性腦中風之在台灣的中國人，APOE基因扮演著部分的角色。

關鍵字

apolipoprotein E ； 缺血性腦中風 ； 台灣

並列摘要

The aim of this study was to clarify whether the apolipoprotein E gene (APOE) is related to ischemic stroke subtypes in Taiwan's Chinese population. Using the classification of Cerebrovas-cular Diseases Ⅲ, 143 patients with lacunar infarction, 114 patients with atherothrombotic infarction, and 112 healthy controls were enrolled. APOE genotype was determined using polymerase chain reaction. Regarding the distribution of APOE genotypes, the frequency of ε3/ε4 genotypes in lacunar patients was significantly different from that in control subjects, by logistic regression, using ε3/ε3 as a reference group. There was no significant difference between atherothrombotic patients and the control group in the distribution of APOE genotypes or alleles. The present finding suggests that there is a probable association between ε3/ε4 genotype and lacunar infarcts, but not atherothrombotic infarcts. This indicates that genetic factors may play a role, at least partially, in lacunar infarction in Taiwan's Chinese population.

並列關鍵字

apolipoprotein E ； ischemic stroke ； Taiwan