In this paper, objective of sampling is to determine where ”hot spots” are present. Spatial analysis method is presented to assess the capability of searching for hot spots of sampling strategy, includes Spatial Simulated Annealing (SSA) and grid sampling strategy. The results indicate the Spatial Simulated Annealing is better than grid sampling design when searching for hot spots. Grid sampling design has the higher miss rate than Spatial Simulated Annealing when deal with the same pollution site with same sampling density.