Application of Rapid Prototyping Technology in Development of Continuous Implanters for Dermal Papilla Cells

應用快速成型技術於連續式毛囊真皮乳頭細胞植入器之開發

鄭逸琳(Yih-Lin Cheng) ； 梁耀中(Yao-Chung Liang)

《中國機械工程學刊》 34卷3期 (2013/06) Pp. 245-252

摘要

現今治療雄性禿的方法成效有限；而近年研究發現，體外大量增生毛囊真皮乳頭細胞後植入禿髮處，可誘導毛囊新生。但目前尚無適合之連續植入器，以縮短前置作業時間、提高植入速度與控制植入深度。本研究開發連續式細胞團植入器，可將半固體狀的細胞團放入「彈匣」中，再利用針具推送進入皮膚。植入器的設計有三種－自動撐開式、條狀彈匣式與轉盤彈匣式。透過快速成型技術製作出植入器原型，並進行模擬測試，評估其植入效率與植入深度。結果發現條狀彈匣式為最可行且適合連續細胞團植入之設計。

並列摘要

The existing ways to treat androgenetic alopecia have their limited effects. The recent study found that implanting massively in-vitro proliferated dermal papilla cells into the bald areas could induce the transdifferentiation of epidermis into hair follicles. However, there are no suitable continuous implanters for implanting the dermal papilla cell aggregates to achieve shorter preparation time, higher implanting speed, and controllable implanted depth. In this research, continuous implanters, which can place semi-solid dermal papilla cells in the cartridge and push the cells into the dermis through a needle, were developed. Three designs were investigated- auto-expand type, bar-cartridge type, and rotary-cartridge type. With the help of Rapid Prototyping technology, the implanter prototypes were generated for simulated implantation tests. Implanting efficiency and implanted depth were two major concerns in the evaluation. The results showed that the bar-cartridge type implanter is the most feasible and suitable design among three designs for continuously implanting the cell aggregates.

並列關鍵字

Rapid Prototyping ； Implanter ； Alopecia ； Dermal Papilla Cells