The purpose of this article was to introduce the importance and principles of the nurse role in emergency medical services at mass gatherings. Accidents easily happen in situations when large groups of people are gathering with exciting activities. Delayed medical intervention for accidents may result in an irreversible and life threatening situation. Therefore, equipment preparation and accident prediction before the activity; prompt medical and nursing intervention during the activity; discussion and evaluation after the activity, are the main principles for emergency medical services at mass gatherings. In such circumstances, the efficiency of medical services is reliable for life saving techniques and cooperative attitudes among health team members.