Transmission of human influenza is by droplets and fine droplet nuclei droplet and avian influenza is likely to become human-to-human high transmission and cause high rate of death, so we have to carry out. Precaution of isolation is necessary to prevent nosocomial spread of the disease. Infection control of H5N1 influenza involves standard precautions, droplet precautions, contact precautions, and airborne precautions. The main strategy includes washing hands, use of personal protective equipment; appropriate handling of patient care equipment and soiled linen; environmental cleaning and spills-management; and appropriate handling of waste.