The purpose of this study was to explore the effect of support groups on a caregiver’s quality of life. A quasiexperimental pre-test control group design was used in this study. The research instrument used was a caregiver's questionnaire about health-related quality of life. From October 2004 to April 2005, a total of 100 caregivers of stroke patients were assigned to experimental and control groups of 50 persons each in a medical center. There were two rounds of data collection: pre-test and during six-month follow-up. The result of the study showed that the experimental groups and control groups made much more progress than former intervention in their quality of life after six months. The quality of life was significantly improved in the experimental groups as compared with those of the control groups after six months. The recommendation based on the results of this study are that caregiver support groups should be promoted as a conventional mode of care, incorporated into groups, to enrich the caregiver's quality of life.