Malignant pleural mesothelioma is a rare type of lung cancer. The main cause of this cancer is related to the exposure to an asbestos environment. Surgical treatment can not remove the tumor completely. Radiation therapy and chemotherapy are ineffective in treating malignant pleural mesothelioma. Palliative therapy seems to be the only preferred treatment choice. This article describes the nursing process of taking care of a primary sufferer of malignant pleural mesothelioma of physical and mental pain. Data was collected from patient observation, patient interview, and the analysis using ”Gordon's 11 items of functional healthy condition”. The results showed patient health problems included: altered nutrition-less than body requirements, activity intolerance, sleep pattern disturbance, fluid volume excess, hyperthermia and powerlessness. By attaining a positive interaction with the patient, utilizing professional nursing skill, providing direct nursing and related nursing care support, the patient's health condition was improved. As a consequence, the patient was able to transfer out of the hospital. It is hoped that the knowledge learned from this nursing experience can provide substantial benefits to clinical staff in their practice with such patients.