Knowledge is advancing and expanding in order to offer more effective, safer, and higher quality nursing care to patients, evidence-based nursing practice needs to become the essential ability of professional personnel. This article looks at the process of evidence-based nursing practice in one medical center as an example. The methods include: conducting book club, participating in the institute's internal and external contests, conjugating evidence-based nursing and nursing advancement, participating in seminar reports in the institute, checking the process of evidence-based nursing in the wards, drafting the action scheme, revising norm based on evidence, etc. This paper shares the experiences of evidence-based nursing implementation.