A Facilitative Effect of Pyridoxine on Dark Adaptation

鹽酸吡哆醇對於暗適應之促進作用

方懷時(H. S. Fang)

《The Chinese Journal of Physiology》 19卷1期 (1963/06) Pp. 1-6

摘要

試驗時施用平流電，故可使那蓋氏暗適應計之光度穩定不變。由靜脈注射50亳克之鹽酸吡咚醇，可使受檢者之感光閾降低，暗適應之能力增強，此增強作用可維持6-8小時。若劑量增加至100毫克，則暗過應之能力更為增強，且可維持約24小時之久。關於視紅之化學反應及暗適應能力之關係，曾加以討論。

並列摘要

Dark adaptation in two healthy male subjects was studied by means of a Nagel's adaptometer. About one hour after intravenous administration of 50 mg of pyridoxine hydrochloride the subjects showed some improvement in rod or peripheral dark adaptation with corresponding lowering of threshold lasting for 6-8 hours. Greater improvement was shown in dark adaptation after 100 mg of pyridoxine, and the effect lasted for about 24 hours. After 1-3 hours of the latter dose of pyridoxine the reduction in final threshold was 0.28-0.34 log micromicrolamberts. The relationship between the chemical reaction of rhodopsin system and the dark adaptability was discussed.