Thyroid and Gonadal Status on Some Bile Parameters and Serum Cholesterol

甲狀腺與性腺情況對若干膽汁成份與血清膽固醇類之影響

穆瑞運(J. Y. Mu) ； 柳安昌(A. C. Liu)

《The Chinese Journal of Physiology》 19卷1期 (1963/06) Pp. 107-129

摘要

以甲狀腺摘除、性腺摘除，飼餵甲狀腺製劑及注射性徵素四者之一或是其他組合，於事前預備正常大白鼠，在氨基甲酸乙酯麻醉下，研究其膽汁中若干成份或血精中膽固酵類之改變。大多數成份之濃度在自然與任何人為之求偶期（求偶間期及在任何兩個不同人為之求偶期）求偶間期間，在我們之實驗情況下。呈現顯著之差異。在以自然求偶期與人為求偶間期或人為求偶期與自然求偶間期膽醉與膽汁膽固酵之濃度相互比較，才看到濃度變異和自然情況一樣，在人為的求偶期比在人為的求偶間期為高。在一個成份一定的內分泌情況下，均有一個未知時間多人之暫時不穩定情況，因各補償作用加入而更行複雜。在兩性間，每一成份都有單獨的表現，且變異情況一致，以及在統計上顯著性之隨便出入，在兩性間不像有什麽性特性。甲狀腺與性腺之功能及有關各點曾經略於置論。

並列摘要

By preparing rats with thyroidectomy, gonadectomy, thyroid feeding and estrone injection singly or in various combinations before hand, changes of some bile parameters and serum cholesterol were studied under urethane. The concentrations of most parameters varied significantly between natural estrus (diestrus) and any induced estrus (diestrus) as well and as freely as between any paired comparison of induced estrus (diestrus) under the afore mentioned experimental conditions. Only when the cholic acid and bile free cholesterol concentrationwas examined crossly,did the change become statistically higher in natural estrus than in induced diestrus or vice versa. Within unknown duration, each parameter under different hormonal status varied significantly its concentration with time, demonstrating the existence of a transitional instability complicated by diversified compensatory factors. On evidences of independent but similar trend of change of each parameter between ”sexes” and inconsistency of significance in the series, no sex specificity was deemed probable. The role of hyper-and hypofunction of thyroid and gonads on the parameters and related points of interest was discussed.