Ovarian Activity and Certain Drugs on Uterine and Ileal Motility of the Rat

卵巢內分泌和某些藥物對大白鼠子宮和廻腸動作的影響

柳安昌(A. C. Liu) ； 楊志剛(T. K. Young)

《The Chinese Journal of Physiology》 19卷1期 (1963/06) Pp. 15-29

摘要

自然和模仿的卵巢內分泌影響大白鼠子宮和廻腸的動作。子宮動作的平均幅恒較廻腸者大，但廻腸動作的頻率則較子宮者快。二者動作的平均幅度均自求偶前期起著增加。子宮在求偶後期動作之平均幅度最大，廻腸則在求偶期最大。二者動作的頻率在實驗的各種情況下，均不一律。用孕婦尿喂卵巢切除之大白鼠後，子宮和廻腸動作的平均幅度均增加，同法處置雄性大白鼠亦增加其廻腸動作的平均幅度。將所有資料用統計方法處理，並用對照圖比較後，推定此二器官對內在和外來之卵巢內分泌有大致相同的表現，並可受許多未知因素的影響。雌性和雄性大白鼠廻腸對雌性素的反應較子宮靈敏。本篇擬具對照圖以供參考採用，並提供若干可能引起動作變化的建議。

並列摘要

Effects of natural and induced ovarian activity and certain drugs were studied on rat uterine and ileal motility. The mean uterine amplitude(motility) was much greater while the mean ileal frequency was much faster than the other. Each mean amplitude increased from proestrus on, with a maximum for uterus in metaestrus and for ileum in estrus, when mean frequency of both was random under all conditions studied. Ovariectomy reduced mean uterine amplitude more than mean ileal amplitude. Treating spayed rats with pregnancy woman urine or estrone increased both uterine and ileal mean amplitude. Treating the male rat similarly also increased its mean ileal amplitude. When all findings were statistically treated and diagrammatically contrasted, it was deduced that both organs behaved qualitatively similar to endogenous and exogenous ovarian hormones and that their activity could be modified by many unknown factors. Significantly the ileum of the female and male rat was more sensitive to estrogen than the uterus. A contrast diagram was suggested and evidences for possible variation of motility presented and discussed.