Influences of Adrenergic and Histaminic Blockades Upon the Effects of Shock Plasma on the Renal Artery of the Rabbit

Lu, H. H., R. H. Liu and I. L. Kou. Influences of adrenergic and histaminic blockades upon the effects of shock plasma on the renal artery of the rabbit. Chinese J.Physiol.22(3):126-132,1977.This study was undertaken to determine whether and to what extent circulating catecholamines and histamine contribute to the cause of the increase in renal vascular resistance during hemorrhagic shock. Experiments were performed using isolated renal arterial strip of the rabbit. Shock plasma was obtained from rabbits in the terminal state of hemorrhagic shock. It was found that both control and shock plasmas caused an increase in tension of the vascular strip. The tension development caused by the shock plasma was significantly higher than that caused by the control plasma either before or after treatment with metiamide, diphenhydramine, propranolol and phentolamine. The effects of the plasmas were potentiated slightly by metiamide and propranolol and suppressed markedly by diphenhydramine and phentolamine. After acombined treatment of the strip with diphenhydramine and phentolamine, the control plasma lost its effect completely while the shock plasma remained effective in causing contraction of the strip although to a much less extent. The higher concentration of K(superscript +)in the shock plasma was not responsible for the difference in actions between these two plasmas. The results suggest that the increase in renal vascular resistance during hemorrhagic shock is related to the presence in the shock plasma considerable amounts ofcatecholamines, histamine and certain substance(s) which is either vasoactive per se orcapable of causing release from the vascular tissue some vasoactive substance(s).

並列關鍵字

Hemorrhagic shock ； Shock plasma ； Adrenergic blockades ； Histaminic blockades ； Renal artery

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