Contribution of Regional Circulations to the Pulmonary Edema and Hemorrhage Induced by Epinephrine

腎上腺素引發肺水腫及出血中局部循環之參與程度

陳幸一(H. I. Chen) ； 陳樹仁(S. J. Chen) ； 郭立(L. Kuo) ； 曾興達(S. D. Tzeng)

《The Chinese Journal of Physiology》 22卷4期 (1978/12) Pp. 141-148

摘要

在麻醉及切除迷走神經後之大白鼠，利用靜脈注射大劑量的腎上腺素以引發肺水腫及出血。注射腎上腺素100及200微克/公斤後之肺指數（肺重/體重×100）分別為1.46±0.20及1.78±0.24。除去雙腿及尾部之循環後，肺水腫及出血之程度稍微減輕，肺指數分別為1.24±0.18（腎上腺素100微克/公斤）及1.54±0.19（200微克/公斤）。結紮腹部主動脈及腔靜脈後，由於腎上腺素引起的肺病變明顯減輕，其肺指數分別為0.62±0.10（腎上腺素100微克/公斤）及0.71±0.09（200微克/公斤），僅略高於正常之肺指數0.54±0.06。分析局部循環參與此肺病變之百分比，結果顯示：對於注射腎上腺素100及200微克/公斤引起肺水腫及出血中，橫膈以上的循環僅分別參與8.7％及13.7％，而雙腿合尾部循環分別供給23.9％及21.0％之病變。最主要的部位為腹腔循環，由於注射腎上腺素引起全身血管收縮，移積血量於肺部而產生肺水腫及出血，65％以上的病變乃由於腹部循環血量減少而引起。

並列摘要

Chen, H. I., S. J. Chen, L. Kuo, and S. D. Tzeng. Contribution of regional circulations to the pulmonary edema and hemorrhage induced by epinephrine. Chinese J. Physiol. 22(4): 141-148, 1978. In anesthetized and vagotomized rats, pulmonary edema and hemorrhage (PEH) was induced by a large intravenous dose of epinephrine (EP). The values of lung index (LI), which denotes the lung wt/body wt X 100, were 1.46±0.20 and 1.78±0.24 (mean±SD) respectively after an injection of EP, 100 and 200 μg/kg. Exclusion of the hindquarters circulation slightly reduced the extent of PEH, the LI being 1.24±0.18 and 1.54±0.19 for EP of 100 and 200 μg/kg. After occlusion of the abdominal aorta and vena cava, the degree of PEH was greatly reduced. The values of LI were 0.62±0.10 and 0.71±0.09, respectively following an EP injection of 100 and 200 μg/kg. These values were only slightly higher than the normal value of0.54±0.06.An analysis was made to evaluate the relative contribution of regional circulations to the PEH induced by EP. For an injection of EP 100 and 200 μg/kg, the supra-diaphragmatic circulation contributes 8.7% and 13.7% respectively, while the hindquarters circulation 23.9% and 21.0% respectively of the total pulmonary changes. The most significant portion of the circulation is the abdominal circulation which contributes 67.4% and 65.3% to the PEH induced by EP of 100 and 200 μg/kg, respectively.

並列關鍵字

Vasoconstriction ； Blood volume change ； Lung ； Regional vascular beds ； Vagotomy ； Rats