Localization of Inhibitory Mechanisms to Aggressiveness in the Medial Hypothalamus

侵略行為抑制機序在下視丘內側部之定位

尹在信(T. H. Yin) ； 陳幼健(Y. C. Chen)

《The Chinese Journal of Physiology》 22卷4期 (1978/12) Pp. 155-164

摘要

以白鼠為研究對象，先在下視丘之一側作廣泛性之電流破壞，然後在他側之內側部作較小之電流破壞，以觀察侵略反應出現之情形。在實驗之前，兩次手術之間與以後各作一次情緒反應測驗以資比較。經過二次手術之鼠計53隻，手術前後均無食量之增加，但多數在下視丘腹中核有明顯之破壞，何以未發生貪食？原因不明。其中只有7隻表現侵略性行為。組織檢查顯示有侵略行為者其破壞在下視丘後部，並接近腦底，此為唯一之特徵。據推測此破壞可能切斷了與中腦情緒反應管制機序有關之向後投射纖維。

並列摘要

T. H. Yin and Y. C. Chen: Localization of inhibitory mechanisms to aggressiveness in the medial hypothalamus. Chinese J. Physiol., 22(4): 155-164. 1978. Release of aggressive reactions was studied by placing a small lesion on the medial hypothalamus in the rat with previous massive destruction on the contralateral side of the hypothalamus. A set of tests for reactivity to provocations was applied to rats before the operation, after the unilateral lesion, and once more after the bilateral lesions. Bilateral lesions were accomplished in 53 rats. None of them increased food intake even though the ventromedial region was involved in many cases. Only 7 developed signs of aggressiveness. The unique histological feature of the animals showing aggressiveness was that the lesions were confined to the posterior hypothalamus usually sparing the ventromedial nucleus and were close to the base. It was suggested that the lesions might have interrupted the fibers projecting to the midbrain mechanisms for control of emotional reactivity.

並列關鍵字

Hypothalamus ； Aggressive reactions ； Lesions ； Localization ； Inhibitory mechanisms