Inhibition of Substantia Nigra Neurons by Noxious Stimuli in Rats

侵害刺激對大白鼠黑質細胞之抑制

蔡長添(C. T. Tsai) ； 中村彰治(S. Nankamura) ； 岩間吉也(K. Iwama)

《The Chinese Journal of Physiology》 23卷1期 (1979/12) Pp. 25-30

摘要

250～350克的大白鼠經Urethane麻醉後，固定在立體定位儀上，利用玻璃微電極記錄黑質緻密部細胞的自發性放電，並觀察侵害刺激對其放電頻率之影響。結果夾擊尾部或熱水燙尾都减少自發性放電的頻率，同時亦增加放電的振幅。皮下注射Ethylene Diamine-tetraacetic acid(EDTA)，卽給與化學物質刺激痛覺接受體時，亦同樣地觀察到抑制黑質緻密部細胞放電的作用，由此可知侵害刺激有抑制黑質緻密部細胞活動的作用。

並列摘要

Unit discharges of neurons of the substantia nigra, pars compacta (SNC), were recorded in urethane-anesthetized rats. While painful stimuli or heat thermal stimuli were applied to the skin and deep tissues, spontaneous firings of SNC neurons were decreased in the firing rate with the spike amplitudes more or less increased. A similar suppression of SNC neurons was obtained by stimulating pain receptors chemically with intradermal injection of ethylene diaminetetraacetic acid.

並列關鍵字

Substantic nigra ； Pain EDTA