Effects of L-DOPA on Metabolic, Respiratory and Vasomotor Activities as Well as Body Temperatures in Rats

L-DOPA對于大白鼠之新陳代謝，呼吸和血管舒縮活動性以及體溫之影響

林茂村(M. T. Lin) ； 張炳齡(A. Chandra) ； 高貞齡(C. L. Kau) ； 孫麗泰(R. G. Sun)

《The Chinese Journal of Physiology》 23卷1期 (1979/12) Pp. 31-38

摘要

在攝氏八度、二十二度和三十度的室溫中觀測L-DOPA對於大白鼠之新陳代謝，呼吸與血管舒縮活動性以及體溫之影響。直接將L-DOPA注入側腦室，在攝氏八及二十二度室溫中，可引起體溫下降。此等降溫作用乃由於新陳代謝率下降之故。同時可見皮下血管收縮但未引起呼吸反應之變化。然而，在三十度室溫中，L-DOPA則引起體溫上升。此等升溫作用乃由於血管收縮之故。此時新陳代謝率及呼吸反應未見變化。由本結果推論L-DOPA抑制了大白鼠的產熱及散熱機轉。

並列摘要

The effects of L-DOPA on metabolic, respiratory and vaso-motor activities as well as body temperatures were assessed in conscious rats at different ambient temperatures(T(subscript a))of 8,22 and 30℃. Direct administration of L-DOPA into the lateral cerebral ventricle of rats produced a dose-dependent hypothermia at both 8 and 22℃ T(subscript a). The hypothermia in response to L-DOPA was due to a decrease in metabolic heat production. There was a decrease in cutaneous temperatures with no change in respiratory evaporative heat loss. However, in the heat(30℃ T(subscript a)), intraventricular administration of L-DOPA produced a dose-dependent hyperthermia. The hyperthermia was due to cutaneous vasoconstriction (as estimated by a decrease in cutaneous temperatures). There was no change in either metabolic heat production or respiratory evaporative heat loss. The data indicate that L-DOPA inhibits both heat production and heat loss mechanisms in rats.

並列關鍵字

L-DOPA ； Hypothermia ； Hyperthermia ； Metabolism ； Respiration ； Vasomotor activity