Effects of Lanatoside C and Nitroprusside on the Cardiovascular Function of the Experimental Myocardial Infarction in the RAT

Lanatoside C及Sodium Nitroprusside對實驗心肌梗塞之心臟血管機能效果

陳瑞芬(Ruei-Feng Chen) ； 黃廷飛(Ting-Fei Huang)

《The Chinese Journal of Physiology》 27卷1期 (1984/06) Pp. 45-54

摘要

毛地黄對急性心肌梗塞引起的心臟衰弱往往引起嚴重的不整脈之不良效果。因此使用毛地黄治療心肌梗塞後之心臟衰弱仍有爭論。近年來以血擴大劑nitroprusside治療可減輕心臟負荷，進而改善心臟血管機能之良好效果，本實驗檢討Lanatoside C(LC)及nitroprusside(NP)對大白鼠實驗心肌梗塞之心臟血管機能之效果做比較。每天投與LC 0.4及0.8 mg/kg或NP4及8 mg/kgI.P.連續七天其結果L/C及NP在冠狀動脈結紮後一小時後，血壓下降，心跳減慢，ECG及VCG顯著變化。尤其ST變化顯著，但七天後各種變化減退。而且七天後對心肌梗塞大小，NP較LC有顯著縮小。

並列摘要

Chen, R. F., and T. F. Huang. Effects of lanatoside C and nitroprusside on the cardiovascular function of the experimental myocardial infarction in the rat. Chinese J.Physiol.27(1):45-54,1984.The effects of lanatoside C(LC)and sodium nitroprusside (NP)on blood pressure, heart rate, ECG and VCG of the experimental infarction in rats were studied. LC in doses of 0.4 and 0.8 mg/kg orally or NP in doses of 4 and 8mg/kg i.p. were administered daily for 7 days after the coronary ligation. Both agents lowered blood pressure, decreased heart rate, and modified profoundly ECG and VCG patterns 1hr after the coronary ligation, but these effects attenuated 7 days later. The infarct size after 7 days was significantly smaller with NP than with LC treatment.

並列關鍵字

Lanatoside ； Nitroprusside ； Myocardial Infarction ； Rat