Multiple Inhibitory Actions of the Paramedian Reticular Nucleus-Effects on Blood Pressure and Motor Activities in Rats

延腦旁中線網狀核對大白鼠血壓及活動量之多種抑制作用

李小媛(Eminy H. Y. Lee) ； 洪嘉麗(J. L. Huang) ； 宋穎如(Y. J. Sung) ； 蔡作雍(C. Y. Chai)

《The Chinese Journal of Physiology》 33卷1期 (1990/03) Pp. 49-61

摘要

旁中線網狀核是後延腦靠近中線的一個三角形區域，電生理與生化實驗均證實此神經核是一個重要的抑心區域，可調節許多心臟血管之功能。目前實驗結果證實其對多種行為量測也有抑制的作用。電破壞此區域後會顯著促進大白鼠的活動量，順時鐘及逆時鐘轉向行為以及增加刻板式行為，同時也增加活動的紊亂性。破壞孤獨核及部份迷走神經的背側運動核也會影響心跳變慢及血壓降低等現象，但不明顯影響活動量。而破壞中腦的網狀核則對心跳、血壓及活動量均無明顯效果。這些研究結果除證實了以前所發表有關旁中線網狀核對許多心臟血管系統的生理現象有抑制作用外，也顯示出此神經細胞核對多種活動及行為的抑制作用。因而此核可能在中樞神經系統中對多種生理功能扮演一致的抑制角色。

並列摘要

The paramedian reticular nucleus(PRN)is a triangle midline structure located in the caudal medulla. Electrophysiological and biochemical evidence has suggested that PRN is an important depressor area, and it regulates various cardiovascular functions. The present results have demonstrated that PRN also plays an inhibitory role in a variety of behavioral functions. Lesions of this nucleus produced augmentations of many behavioral measures including: locomotor activity, clockwise and anti-clockwise turnings, as well as stereotyped behavior in rats. It also produced an increased and a more randomized pattern of locomotion. Destructions of the area of nucleus of solitary tract, which affects bradycardia and sometimes hypotension; as well as the midbrain reticular formation, which does not show any cardiovascular responses, yielded much less significant effects. These results confirm previous physiological findings from our laboratory and further suggest that PRN is a unique and independent area which exerts multiple inhibitory actions upon various physiological and behavioral functions in animals.

並列關鍵字

paramedian reticular nucleus ； nucleus of solitary tract ； midbrain reticular formation ； cardiovascular and behavioral inhibitions ； electrolytic lesion ； activities ； rat