- 期刊
Different Relaxations Between L-Arginine and Acetylcholine in Spontaneously Hypertensive Rat Aortae Treated with N(superscript ω)-Nitro-L-Arginine
N(上標ω)-nitro-L-arginine對L-arginine及Acetylcholine在高血壓鼠離體胸主動脈舒張作用不同
摘要
本實驗目的在比較L-arginine和acetylcholine對正常鼠和高血壓鼠離體胸主動脈舒張作用，以進一步觀察血管內皮功能在高血壓時所扮演的角色。結果顯示此二種舒血管作用在正常鼠顯著大在於高血壓鼠。而L-arginine在正常鼠與高血壓鼠舒血管作用之差，則明顯小於acetylcholine。除此之外，血管在去內皮情況下，對phenylephrine之收縮作用不論是在正常鼠或高血壓鼠均被增強，而此現象在正常鼠顯著大於在高血壓鼠，至於對acetylcholine及L-argin-ine的舒張作用則完全消失。更且，N(上標 ω)-nitro-L-arginine，一種NO合成抑制劑，顯著抑制acetylcholine在正常鼠和高血壓鼠的舒張血管作用，但對L-arginine在高血壓鼠不但無抑制反而更增強其舒張血管作用。綜合以上結果顯示，高血壓時血管內皮合成NO的作用明顯降低，此可用於說明其導致高血壓之部份原因。
關鍵字
無資料並列摘要
Yen, M.H., K.L. Huang, and C.C. Wu. Different relaxations between L-arginine and acetylcholine in spontaneously hypertensive rat aortae treated with N(superscript ω)-nitro-L-arginine. Chinese J. Physiol. 34(3): 257-266, 1991. The relaxing effects of L-arginine and acetylcholine were compared on contracted thoracic aortic rings from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) in the present study. Results demonstrated that both vasodilatations induced by L-arginine and acetylcholine in WKY were greater than those in SHR. The maximal relaxation induced by acetylcholine was greater than that induced by L-arginine in both WKY and SHR. However, the difference of relaxation induced by L-arginine was less than that induced by acetylcholine between WKY and SHR. In addition, phenylephrine caused contractions, which were similarly augmented after the removal of the endothelium or the treatment with N(superscript ω)-nitro-L-arginine in aortic rings from WKY and SHR. On the aorta preparations from SHR a larger contraction was produced by phenylephrine and the maximal relaxations produced by L-arginine and acetylcholine were significantly reduced. These effects were not seen after the endothelium had been removed. We suggest that the ability of the endothelium to synthesize NO may be reduced in hypertension.
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