- 期刊
Mechanisms of Adrenaline-Induced Antinociception in Mice
並列摘要
Peng, Y.I., H.J. Liu, L. Guo, and T.C. Fu. Mechanisms of adrenaline-induced antinociception in mice. Chinese J. Physiol. 35(3): 205-210, 1992. Infusion of adrenaline into the upper lumbar subarachnoid space in lightly anesthetized mice produced a significant elevation of the nociceptive threshold as quantitated by tail flick test. The antinociceptive effect of adrenaline was dose-dependent and antagonized equally by pretreatment with either alpha-l selective antagonist prazosin or alpha-2 selective antagonist yohimbine at a dose of 0.05μg/5μl/mouse. This antinociceptive effect of adrenaline was also blocked by pretreatment with beta antagonist propranolol or opiate antagonist naloxone at higher doses, i.e., 0.5μg and 1.0μg/5μg/mouse, respectively. These results suggest that the antinociceptive mechanisms of adrenaline at the lumbar spinal level in the mouse seem to be mediated not only through alpha- and beta-adrenergic pathways but also through opiate system.
延伸閱讀
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