- 期刊
Betel Quid Chewing Damaged Gastric Mucosa: Protective Effects of Cimetidine and Sodium Bicarbonate
並列摘要
The effects of cimetidine and NaHCO3 on gastric acid back-diffusion (either the H(superscript +) loss or the Na(superscript +), K(superscript +) and Ca(superscript ++) gain in the gastric lumen) and mucosal ulceration were studied in rats with chronic feeding of betel quid chewing (BQC)- or its individual component-containing food. After 30 and 90 days of feeding, the animal was fasted for 24 hrs and vagotomized. An acid solution (100 mM HCl plus 54 mM NaCl) with or without drugs was irrigated in the rat stomach for 3 hrs. The results indicated that BQC and its individual component produced a variety of change in enhancement in acid solution-induced acid back-diffusion and mucosal hemorrhagic ulceration but in decrease of gastric mucus secretion. These parameters were dose-dependently reversed by intragastric cimetidine (50-300 mg/kg)in BQC-treated rats. Similar but lesser effect than cimetidine (300 mg/kg) was obtained by intragastric administration of NaHCO3 (52 mg/kg). It is concluded that in BQC-or its component-feeding rats, the enhancement in acid back-diffusion and the reduction in mucus secretion are at least in part responsible for the formation of hemorrhagic ulceration which can be inhibited by intragastric cimetidine or NaHCO3.
延伸閱讀
- 張巧宜（2015）。The relationship between the addiction of betel-quid chewing and anxiety, depression and oral potentially malignant disorders〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://doi.org/10.6832/KMU.2015.00047
- 江偉誌（2014）。Study of Trace Elements and Malondialdehyde in Gastric Juice〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-1812201417174400
- 吳逸氏、楊奕馨、蔡吉政（1997）。The Relationship between Betel Quid Chewing and Periodontal Disease。中華民國牙周病醫學會雜誌，2(4)，243-243。https://www.airitilibrary.com/Article/Detail?DocID=a0000071-199712-201301020009-201301020009-243
- Ho, A. S., Tsao, W. L., Yeh, C., Hsieh, J. P., & Hsu, C. T. (1994). Effect of Oral Omeprazole on Active Duodenal Ulcer Reduction, Fasting Serum Gastrin and Pepsinogen I Level. Journal of Medical Sciences, 14(6), 389-396. https://www.airitilibrary.com/Article/Detail?DocID=10114564-199406-201306270014-201306270014-389-396
- Wu, L., Li, F., & Gong, X. (2021). Severe Cadmium Poisoning with Multiple Organ Dysfunction Syndrome Caused by Long-term Betel Quid Chewing: A Case Report. Frontiers in Science and Engineering, 1(5), 79-82. https://doi.org/10.29556/FSE.202108_1(5).0011