- 期刊
Greater Effects of Fluoxetine and its Combination with(-)-Pindolol in Elevating Hypothalamic Serotonin in Rats During Dark Hours
並列摘要
Isovolemic hemodilution with polymerized bovine hemoglobin(PoBH)was tested as a means ofpreventing infarction in a rabbit model of focal cerebral ischemia.The animals were divided into one control group and one hemodilution group.All animalsunderwent two hours of ischemia,caused by clipping the left internal carotid artery,the anteriorcerebral artery,and the middle cerebral artery,followed by 4 hours of reperfusion.In the control group,the hematocrit was not manipulated(mean±SE:33.8±1.3%),while in the hemodilution group,the Hctwas reduced to 12.5±1.9% by exchange of blood with PoBH,before clipping the cerebral vessels.Staining with 2,3,5- triphenyltetrazolium chloride(TTC)was used to evaluate the infarct size.The infarct volume was 427±52 mm^(3)in the control animal,and 1026±311 mm^(3)(p＜0.01 whencompared with the control group)in the animal hemodiluted with PoBH.PoBH hemodilution was found to be associated with vasoconstriction.This pathologicalvasoconstriction probably counteracted any beneficial effects from the lowered viscosity and explainsour negative results.Vasoconstriction has to be overcome before hemodilution can have its beneficialeffect in reducing the cerebral ischemia.
延伸閱讀
- 陳怡安（2004）。Part I: The effect of prenatal exposure to morphine on the expression of PSD-95 and synaptophysin in the hippocampus of developing rats. Part II: The therapeutic effect of serotonin reuptake inhibitor on the expression of morphine withdraw syndrome in ne〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714562754
- Chang, S. T., Tung, C. S., Chuang, C. H., Lin, Y. L., Lee, A. R., & Liu, Y. P. (2011). The Effects of Reboxetine with Modafinil on Noxious Tail Pinch-induced Sensorimotor Gating Reactivity in Rats. Journal of Medical Sciences, 31(1), 27-35. https://doi.org/10.6136/JMS.2011.31(1).027
- Abramova, M., Calas, A., Thibault, J., & Ugrumov, M. (2000). Tyrosine Hydroxylase in Vasopressinergic Axons of the Pituitary Posterior Lobe of Rats Under Salt-Loading as a Manifestation of Neurochemical Plasticity. Neural Plasticity, 2000(), 179-191. https://doi.org/10.1155/NP.2000.179
- RA, H., EA, E. H., LA, H., & WM, E. S. (2017). The Prophylactic and Therapeutic Effects of Safranal and Selenite on Liver Damage Induced by Thyrotoxicosis in Adult Male Rats. International Journal of Clinical Pharmacology & Toxicology (IJCPT), 6(3), 270-279. https://doi.org/10.19070/2167-910X-1700045
- Riyami, B. A., Tahir, M. E., Maskari, S. A., Johnson, E. H., & Saleh, J. (2014). Acute Effects of Exogenous Hormone Administration on Postprandial Acylation Stimulating Protein Levels in Ovariectomized Rats after a Fat Load. Journal of Nutrition and Metabolism, (2014), 123-129. https://doi.org/10.1155/2014/510916