Activation of Gonadotropin-Releasing Hormone Receptors Produces Neuronal Excitation in the Rat Hippocampus

Farn Lu ； Jung-Mou Yang ； Jian-Nan Wu ； Yao-Chung Chen ； Yu-Hsun Kao ； Che-Se Tung ； San-Nan Yang

《The Chinese Journal of Physiology》 42卷2期 (1999/06) Pp. 67-71

並列摘要

Whole-cell patch-clamp recordings of evoked action potentials were made in CA1 and CA3pyramidal neurons of rat hippocampal slices.Previously we have demonstrated that activation ofgonadotropin-releasing hormone(GnRH)receptors induces a long-lasting enhancement of synaptictransmission mediated by ionotropic glutamate receptors in CA1 pyramidal neurons of rat hippocampalslices.Here,we further studied whether activation of GnRH receptors could modulate intrinsicneuronal excitability in CA1 and CA3 pyramidal neurons of rat hippocampal slices.The use of a specificGnRH analog,leuprolide(10^(-8)M),elicited a relatively long-term increase in evoked action potentials inCA1 and CA3 pyramidal neurons,respectively.The GnRH receptor-induced increase in evoked actionpotentials in both CA1 and CA3 pyramidal neurons could be abolished by a potent GnRH receptorantagonist,[acetyl-3,4-dehydro-Pro^1,D-p-F-Phe^2,D-Trp^(3,6)]-LHRH(10^(-8)M).The present study suggeststhat activation of GnRH receptors can lead to an increase of intrinsic neuronal excitability of both CA1and CA3 pyramidal neurons in the rat hippocampus,an important integrative region for reproductiveprocess,both endocrinologically and behaviorally.

並列關鍵字

gonadotropin-releasing hormone receptor ； CA1 neurons ； CA3 neurons ； hippocampus ； leuprolide ； neuropeptide